Details of the Drug

General Information of Drug (ID: DMWZ6DK)

Drug Name

Roledumab

Synonyms

DMATRIA; LFB-R593; R-297; R-593; Anti-D human monoclonal antibody, Laboratoire Francais du Fractionnement et des Biotechnologies; R297 antibody (hematological disease), LFB; R297 antibody (hematological disease), Laboratoire Francais du Fractionnement et des Biotechnologies; Anti-RhD antibody (hematological disease), LFB; Anti-rhesus D mAB (hematological disease), LFB

Indication

Disease Entry	ICD 11	Status	REF
Anemia	3A00-3A9Z	Phase 2/3	[1]
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Drug Type

Antibody

Cross-matching ID

DrugBank ID: DB16317
TTD ID: D01ADL

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Blood group Rh(D) polypeptide (RHD)	TTLCKI8	RHD_HUMAN	Not Available	[2]

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Molecular Interaction Atlas (MIA)

MIA Detail

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Molecular Expression Atlas of This Drug

The Studied Disease

Anemia

ICD Disease Classification

3A00-3A9Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Blood group Rh(D) polypeptide (RHD)	DTT	RHD	4.18E-02	0.64	1.13

Molecular Expression Atlas (MEA)

MEA Detail

Jump to Detail Molecular Expression Atlas of This Drug

References

1	ClinicalTrials.gov (NCT02287896) Pharmacokinetics and Safety of Roledumab, in RhD-negative Pregnant Women Carrying an RhD-positive Foetus. U.S. National Institutes of Health.
2	Pharmacokinetics and safety of roledumab, a novel human recombinant monoclonal anti-RhD antibody with an optimized Fc for improved engagement of FCgammaRIII, in healthy volunteers. Vox Sang. 2012 Oct;103(3):213-22.