Details of the Drug-Related molecule(s) Expression Atlas

Silymarin Drug Info

Milk thistle extract; Sabal serrulata extract; 84604-20-6; AN-35849; FT-0656490; A835184; (2S)-3,5,7-trihydroxy-2-[(2S,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-3,4-dihydro-2H-1-benzopyran-4-one; (2S)-3,5,7-trihydroxy-2-[(2S,3R)-3-(4-hydroxy-3-methoxy-phenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]chroman-4-one

Cross-matching ID

PubChem CID

5213

ChEBI ID

CHEBI:125451

CAS Number

CAS 65666-07-1

TTD Drug ID

DMXBYQR

VARIDT Drug ID

DR01185

INTEDE Drug ID

DR1913

General Information of Drug (ID: DMXBYQR)

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Arachidonate 5-lipoxygenase (5-LOX)	TT2J34L	LOX5_HUMAN	Inhibitor	[1]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	Highest Status	REF
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DEYGVN4	UD11_HUMAN	Phase 4	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Arachidonate 5-lipoxygenase (5-LOX)	DTT	ALOX5	4.966	5.133	5.358	6.128

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Arachidonate 5-lipoxygenase (5-LOX)	DTT	ALOX5	7.42E-01	-0.18	-0.25
Arachidonate 5-lipoxygenase (5-LOX)	DTT	ALOX5	1.25E-03	0.43	0.63
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DME	UGT1A1	8.29E-01	-5.44E-03	-2.25E-02
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DME	UGT1A1	4.23E-03	9.31E-02	4.30E-01

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Anti-inflammatory and anti-arthritic activities of silymarin acting through inhibition of 5-lipoxygenase. Phytomedicine. 2000 Mar;7(1):21-4.
2	Role of UDP-glucuronosyltransferase 1A1 in the metabolism and pharmacokinetics of silymarin flavonolignans in patients with HCV and NAFLD. Molecules. 2017 Jan 15;22(1). pii: E142.