Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMXF0NS)

• Drug Name: Norastemizole Drug Info
• Synonyms: Tecastemizole; Soltara; UNII-W5DCO14M05; 75970-99-9; CHEMBL61301; W5DCO14M05; T 1348; 1-((4-Flurophenyl)methyl)-N-4-piperidinyl-1H-benzimidazol-2-amine; 1-(-Fluorobenzyl)-N-(piperidin-4-yl)-1H-benzimidazol-2-amine; 1H-Benzimidazol-2-amine, 1-((4-fluorophenyl)methyl)-N-4-piperidinyl-; Tecastemizole[USAN]; 75970-64-8; Tecastemizole [USAN:INN]; 1-(4-fluorobenzyl)-n-(piperidin-4-yl)-1h-benzimidazol-2-amine; AC1Q4NSA; AC1L3WZJ; Tecastemizole (USAN/INN); SCHEMBL18200; ZINC2303; DTXSID30226877
• Cross-matching ID:
  PubChem CID: 123618
  CAS Number: CAS 75970-99-9
  TTD Drug ID: DMXF0NS

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histamine H1 receptor (H1R)	TTTIBOJ	HRH1_HUMAN	Modulator	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Histamine H1 receptor (H1R)	DTT	HRH1	5.972	5.7	5.816	6.002

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Histamine H1 receptor (H1R)	DTT	HRH1	6.74E-01	0.13	0.43

References

• [1] Effect of tecastemizole on pulmonary and cutaneous allergic inflammatory responses. Clin Exp Allergy. 2007 Jun;37(6):909-17.