Details of the Drug

General Information of Drug (ID: DMXF0NS)

• Drug Name: Norastemizole
• Synonyms: Tecastemizole; Soltara; UNII-W5DCO14M05; 75970-99-9; CHEMBL61301; W5DCO14M05; T 1348; 1-((4-Flurophenyl)methyl)-N-4-piperidinyl-1H-benzimidazol-2-amine; 1-(-Fluorobenzyl)-N-(piperidin-4-yl)-1H-benzimidazol-2-amine; 1H-Benzimidazol-2-amine, 1-((4-fluorophenyl)methyl)-N-4-piperidinyl-; Tecastemizole[USAN]; 75970-64-8; Tecastemizole [USAN:INN]; 1-(4-fluorobenzyl)-n-(piperidin-4-yl)-1h-benzimidazol-2-amine; AC1Q4NSA; AC1L3WZJ; Tecastemizole (USAN/INN); SCHEMBL18200; ZINC2303; DTXSID30226877
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 324.4
  Logarithm of the Partition Coefficient (xlogp); 3.6
  Rotatable Bond Count (rotbonds); 4
  Hydrogen Bond Donor Count (hbonddonor); 2
  Hydrogen Bond Acceptor Count (hbondacc); 4
• Chemical Identifiers:
  Formula: C19H21FN4
  IUPAC Name: 1-[(4-fluorophenyl)methyl]-N-piperidin-4-ylbenzimidazol-2-amine
  Canonical SMILES: C1CNCCC1NC2=NC3=CC=CC=C3N2CC4=CC=C(C=C4)F
  InChI: InChI=1S/C19H21FN4/c20-15-7-5-14(6-8-15)13-24-18-4-2-1-3-17(18)23-19(24)22-16-9-11-21-12-10-16/h1-8,16,21H,9-13H2,(H,22,23)
  InChIKey: SFOVDSLXFUGAIV-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 123618
  CAS Number: 75970-99-9
  TTD ID: D0I5UU

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histamine H1 receptor (H1R)	TTTIBOJ	HRH1_HUMAN	Modulator	[1]

Molecular Expression Atlas of This Drug

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Histamine H1 receptor (H1R)	DTT	HRH1	6.74E-01	0.13	0.43

References

• [1] Effect of tecastemizole on pulmonary and cutaneous allergic inflammatory responses. Clin Exp Allergy. 2007 Jun;37(6):909-17.