Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMYHFUO)

Drug Name

2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-imine Drug Info

Synonyms

CHEMBL214856; 2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-imine; SCHEMBL3385589; Pyrrolo[2,1-b]quinazolin-9(1H)-imine, 2,3-dihydro-; BDBM50194096; 745837-16-5

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 21094663
TTD Drug ID: DMYHFUO

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Acetylcholinesterase (AChE)	TT1RS9F	ACES_HUMAN	Inhibitor	[1]
Cholinesterase (BCHE)	TTEB0GD	CHLE_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Acetylcholinesterase (AChE)	DTT	ACHE	1.678	1.926	1.766	5.252

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Acetylcholinesterase (AChE)	DTT	ACHE	6.39E-02	-1.07	-1.15

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Homobivalent quinazolinimines as novel nanomolar inhibitors of cholinesterases with dirigible selectivity toward butyrylcholinesterase. J Med Chem. 2006 Sep 7;49(18):5411-3.