Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMYILBE)

Drug Name
Modafinil Drug Info
Synonyms Provigil; Modiodal
Indication
Disease Entry ICD 11 Status REF
Malignant glioma 2A00.0 Approved [1]
Methamphetamine dependence 6C46.2 Approved [1]
Narcolepsy 7A20 Approved [2]
Pain MG30-MG3Z Approved [1]
Postpoliomyelitis syndrome Approved [1]
Traumatic brain injury NA07.Z Approved [1]
Bipolar disorder 6A60 Phase 4 [3]
Brain injury NA07.Z Investigative [4]
Therapeutic Class
Neurology Agents
Cross-matching ID
PubChem CID
4236
ChEBI ID
CHEBI:77585
CAS Number
CAS 68693-11-8
TTD Drug ID
DMYILBE
VARIDT Drug ID
DR00411
INTEDE Drug ID
DR1104
ACDINA Drug ID
D00442

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dopamine transporter (DAT) TTVBI8W SC6A3_HUMAN Modulator [5]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID Highest Status REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Approved [6]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Dopamine transporter (DAT) DTT SLC6A3 4 2.609 5.233 3.7
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 11.692 6.58 4.984 9.089
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Malignant glioma
ICD Disease Classification 2A00.0
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Dopamine transporter (DAT) DTT SLC6A3 1.08E-03 -3.08 -1.99
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 1.76E-01 1.26E-01 8.27E-01
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Modafinil FDA Label
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3 ClinicalTrials.gov (NCT01965925) Targeting Circadian and Cognitive Dysfunction in Bipolar Disorder With Modafinil. U.S. National Institutes of Health.
4 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
6 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.