Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMYSBN3)

Drug Name

AZD-9272 Drug Info

Synonyms

AZD 9272; 327056-26-8; UNII-54SQ9B412I; AZD9272; 54SQ9B412I; 3-fluoro-5-[3-(5-fluoropyridin-2-yl)-1,2,4-oxadiazol-5-yl]benzonitrile; CHEMBL2164550; 3-Fluoro-5-(3-(5-fluoropyridin-2-yl)-1,2,4-oxadiazol-5-yl)benzonitrile; RBSPCALDSNXWEP-UHFFFAOYSA-N; SCHEMBL2027395; GTPL6439; CHEMBL2164551; MolPort-039-338-067; ZINC33980255; BDBM50395923; AKOS027470228; HY-110254; AZD9272, > CS-0033119; J3.560.338G; 3-Fluoro-5-[3-(5-fluoro-2-pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile

Indication

Disease Entry	ICD 11	Status	REF
Neuropathic pain	8E43.0	Discontinued in Phase 1	[1]

Therapeutic Class

Analgesics

Cross-matching ID

PubChem CID: 9838729
CAS Number: CAS 327056-26-8
TTD Drug ID: DMYSBN3

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Metabotropic glutamate receptor 1 (mGluR1)	TTVBPDM	GRM1_HUMAN	Modulator	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Metabotropic glutamate receptor 1 (mGluR1)	DTT	GRM1	3.888	3.848	3.711	3.678

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Neuropathic pain

ICD Disease Classification

8E43.0

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Metabotropic glutamate receptor 1 (mGluR1)	DTT	GRM1	2.31E-01	-0.05	-0.2
Metabotropic glutamate receptor 1 (mGluR1)	DTT	GRM1	2.46E-02	0.11	0.74

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6439).
2	Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26.