Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM059CZ)

Drug Name

DPK-060 Drug Info

Synonyms

DP-9011; DP-9012; DP-9013; DP-9011-DP-9013 series (atopic dermatitis/impetigo), DermaGen

Indication

Disease Entry	ICD 11	Status	REF
Atopic dermatitis	EA80	Phase 2	[1]

Cross-matching ID

TTD Drug ID: DM059CZ

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Bacterial Cell membrane (Bact CM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[3]
Teicoplanin	DMAQ2LK	Bacterial infection	1A00-1C4Z	Approved	[4]
Delamanid	DMXE76K	Multi-drug resistant tuberculosis	MG52.00	Approved	[5]
Diphtheria-tetanus vaccine	DM0FSIM	Clostridium infection	1A04	Approved	[6]
D2A21	DMYJ2QB	Burn and burn infection	ND90-NE2Z	Phase 3	[7]
Brilacidin	DMXI9BP	Acute bacterial skin infection	1C41	Phase 2	[8]
LTX-109	DMXEQ0R	Bacterial infection	1A00-1C4Z	Phase 2	[9]
Friulimicin	DMUI8F3	Bacterial infection	1A00-1C4Z	Phase 1	[10]
IDR-1018	DM1RNT7	Bacterial infection	1A00-1C4Z	Phase 1	[11]
Lotilibcin	DMDLTCU	Bacterial infection	1A00-1C4Z	Phase 1	[12]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Cell membrane (Bact CM)	TTXT4D5	NOUNIPROTAC	Enhancer	[2]

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References

1	ClinicalTrials.gov (NCT01447017) A Study of DPK-060 to Investigate Clinical Safety and Efficacy in Patients With Acute External Otitis. U.S. National Institutes of Health.
2	The re-emergence of natural products for drug discovery in the genomics era. Nat Rev Drug Discov. 2015 Feb;14(2):111-29.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
5	Compassionate use of delamanid in adults and children for drug-resistant tuberculosis: 5-year update. Eur Respir J. 2021 May 20;57(5):2002483.
6	2006 drug approvals: finding the niche. Nat Rev Drug Discov. 2007 Feb;6(2):99-101.
7	In Vitro Microbicidal Activities of Cecropin Peptides D2A21 and D4E1 and Gel Formulations Containing 0.1 to 2% D2A21 against Chlamydia trachomatis. Antimicrob Agents Chemother. 2002 January; 46(1): 34-41.
8	Comparative mechanistic studies of brilacidin, daptomycin, and the antimicrobial peptide LL16. Antimicrob Agents Chemother. 2014 Sep;58(9):5136-45.
9	A synthetic antimicrobial peptidomimetic (LTX 109): stereochemical impact on membrane disruption. J Med Chem. 2011 Aug 25;54(16):5786-95.
10	Model membrane approaches to determine the role of calcium for the antimicrobial activity of friulimicin. Int J Antimicrob Agents. 2011 Mar;37(3):256-60.
11	Innate Defense Regulator Peptide 1018 in Wound Healing and Wound Infection. PLoS One. 2012; 7(8): e39373.
12	Bioactive natural products from Lysobacter. Nat Prod Rep. 2012 November 8; 29(11): 1277-1287.