Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM05V8Q)

• Drug Name: 4-aryl quinol derivative 3 Drug Info
• Synonyms: PMID27977313-Compound-22
• Cross-matching ID:
  PubChem CID: 9907134
  CAS Number: CAS 719308-90-4
  TTD Drug ID: DM05V8Q

Molecule-Related Drug Atlas

Drug(s) Targeting Cytoplasmic thioredoxin reductase (TXNRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fotemustine	DMV62ED	Solid tumour/cancer	2A00-2F9Z	Approved	[3]
Spermidine	DMVJNFI	Plaque psoriasis	EA90.0	Phase 3	[3]
Golden phosphorous acetyletic compound 2	DMYJ15A	N. A.	N. A.	Patented	[1]
Terpyridineplatinum(II) complexe 3	DM54EFD	N. A.	N. A.	Patented	[1]
Terpyridineplatinum(II) complexe 4	DMOV86T	N. A.	N. A.	Patented	[1]
Golden phosphorous acetyletic compound 1	DMVAKUI	N. A.	N. A.	Patented	[1]
Acyl oxymethyl acrylamide ester derivative 1	DMXTUE1	N. A.	N. A.	Patented	[1]
PMID27977313-Compound-18	DMIA3GH	N. A.	N. A.	Patented	[1]
Triazole gold complexe 1	DMCWES7	N. A.	N. A.	Patented	[1]
4-aryl quinol derivative 2	DM7TW5Z	N. A.	N. A.	Patented	[1]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[5]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[6]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[7]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[8]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[9]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[10]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[11]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[12]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[13]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cytoplasmic thioredoxin reductase (TXNRD1)	TTR7UJ3	TRXR1_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Protein Interaction/Cellular Processes	[2]

References

• [1] Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556.
• [2] Antitumor quinols: role of glutathione in modulating quinol-induced apoptosis and identification of putative cellular protein targets. Biochem Biophys Res Commun. 2006 Jul 21;346(1):242-51. doi: 10.1016/j.bbrc.2006.05.106. Epub 2006 May 26.
• [3] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [4] Different apoptosis ratios and gene expressions in two human cell lines after sevoflurane anaesthesia. Acta Anaesthesiol Scand. 2009 Oct;53(9):1192-9. doi: 10.1111/j.1399-6576.2009.02036.x. Epub 2009 Jun 30.
• [5] [Mechanisms underlying the effect of arsenic trioxide on proliferation inhibition and apoptosis induction in myeloma cell line u266]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2007 Oct;15(5):982-5.
• [6] Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPAR-dependent pathway. Oncotarget. 2016 Mar 1;7(9):10345-62. doi: 10.18632/oncotarget.7213.
• [7] Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncol Res. 2000;12(9-10):397-408. doi: 10.3727/096504001108747855.
• [8] Comparison of burst of reactive oxygen species and activation of caspase-3 in apoptosis of K562 and HL-60 cells induced by docetaxel. Cancer Lett. 2004 Oct 8;214(1):103-13. doi: 10.1016/j.canlet.2004.03.047.
• [9] Induction of mitochondrial manganese superoxide dismutase confers resistance to apoptosis in acute myeloblastic leukaemia cells exposed to etoposide. Br J Haematol. 2000 Mar;108(3):574-81. doi: 10.1046/j.1365-2141.2000.01852.x.
• [10] Cisplatin-enhanced sensitivity of glioblastoma multiforme U251 cells to adenovirus-delivered TRAIL in vitro. Tumour Biol. 2010 Dec;31(6):613-22. doi: 10.1007/s13277-010-0077-x. Epub 2010 Jul 11.
• [11] Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis. J Cell Physiol. 2000 Jan;182(1):24-32. doi: 10.1002/(SICI)1097-4652(200001)182:1<24::AID-JCP3>3.0.CO;2-6.
• [12] mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin. Biol Chem. 2004 Nov;385(11):1099-103. doi: 10.1515/BC.2004.143.
• [13] Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-B axis: Shedding new light on resistance to Aprepitant. Int J Biochem Cell Biol. 2018 Oct;103:105-114. doi: 10.1016/j.biocel.2018.08.010. Epub 2018 Aug 23.