Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0DIEZ)

Drug Name

UNI-rhIL-11 Drug Info

Synonyms

Recombinant human interleukin 11 (thrombocytopenia), Uni-Bio Science Group; RhIL-11 (thrombocytopenia), Uni-Bio Science Group

Indication

Disease Entry	ICD 11	Status	REF
Thrombocytopenia	3B64	Phase 3	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Interleukin 11 receptor alpha (IL11RA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Oprelvekin	DMTSRI6	Inflammatory bowel disease	DD72	Approved	[3]
BMTP-11	DMB6FMH	Prostate cancer	2C82.0	Phase 1	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interleukin 11 receptor alpha (IL11RA)	TTZPLJS	I11RA_HUMAN	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT01663441) A Phase Study of Genetically Modified Recombinant Human Interleukin-11. U.S. National Institutes of Health.
2	Clinical study of rhIL-11 for prevention and treatment of chemotherapy-induced thrombocytopenia. Ai Zheng. 2002 Aug;21(8):892-5.
3	Oprelvekin: a review of its pharmacology and therapeutic potential in chemotherapy-induced thrombocytopenia. BioDrugs. 1998 Aug;10(2):159-71.
4	Targeting IL11 Receptor in Leukemia and Lymphoma: A Functional Ligand-Directed Study and Hematopathology Analysis of Patient-Derived Specimens. Clin Cancer Res. 2015 Jul 1;21(13):3041-51.