Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0PWX2)

• Drug Name: AUTO2 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Multiple myeloma	2A83	Phase 1/2	[1]

• Cross-matching ID: TTD Drug ID: DM0PWX2

Molecule-Related Drug Atlas

Drug(s) Targeting B-cell maturation protein (TNFRSF17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Idecabtagene vicleucel	DMP1QTS	Multiple myeloma	2A83	Approved	[2]
Belantamab mafodotin	DMBT3AI	Multiple myeloma	2A83	Approved	[3]
Elranatamab	DMG1MW2	Multiple myeloma	2A83	Approved	[4]
Teclistamab	DMGR8JI	Multiple myeloma	2A83	Approved	[5]
Ciltacabtagene autoleucel	DMU2J7Y	Multiple myeloma	2A83	Phase 3	[6]
Bb2121	DMB0UF9	Multiple myeloma	2A83	Phase 2	[7]
LCAR-B38M CAR-T Cell	DMQZJNA	Multiple myeloma	2A83	Phase 2	[8]
Descartes-08	DM63P1W	Multiple myeloma	2A83	Phase 2	[9]
Descartes-11	DM1UO4S	Multiple myeloma	2A83	Phase 2	[10]
CART-19/BCMA	DMVW1GY	Multiple myeloma	2A83	Phase 1/2	[11]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
B-cell maturation protein (TNFRSF17)	TTZ3P4W	TNR17_HUMAN	CAR-T-Cell-Therapy(Dual specific)	[1]
Transmembrane activator and CAML interactor (TNFRSF13B)	TTL9OD4	TR13B_HUMAN	CAR-T-Cell-Therapy(Dual specific)	[1]

References

• [1] ClinicalTrials.gov (NCT03287804) APRIL CAR T Cells (AUTO2) Targeting BCMA and TACI for the Treatment of Multiple Myeloma
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services.
• [3] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
• [4] FDA Approved Drug Products from FDA Official Website. 2023. Application Number: 761345
• [5] FDA Approved Drug Products from FDA Official Website. 2022. Application Number: 761291.
• [6] ClinicalTrials.gov (NCT04181827) A Study Comparing JNJ-68284528, a CAR-T Therapy Directed Against B-cell Maturation Antigen (BCMA), Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) or Daratumumab, Pomalidomide and Dexamethasone (DPd) in Participants With Relapsed and Lenalidomide-Refractory Multiple Myeloma (CARTITUDE-4). U.S. National Institutes of Health.
• [7] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [8] ClinicalTrials.gov (NCT03758417) A Study of LCAR-B38M CAR-T Cells, a Chimeric Antigen Receptor T-cell (CAR-T) Therapy Directed Against B-cell Maturation Antigen (BCMA) in Chinese Participants With Relapsed or Refractory Multiple Myeloma
• [9] ClinicalTrials.gov (NCT03448978) Autologous CD8+ T-cells Expressing an Anti-BCMA CAR in Patients With Myeloma
• [10] Clinical pipeline report, company report or official report of Cartesian Therapeutics.
• [11] ClinicalTrials.gov (NCT03455972) Study of T Cells Targeting CD19/BCMA (CART-19/BCMA) for High Risk Multiple Myeloma Followed With Auto-HSCT