Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0TH9A)

• Drug Name: Bimosiamose Drug Info
• Synonyms: TBC 1269; TBC-1269

Indication

Disease Entry	ICD 11	Status	REF
Atopic dermatitis	EA80	Phase 2a	[1]
Chronic obstructive pulmonary disease	CA22	Phase 2a	[1]
Psoriatic disorder	EA90	Phase 2a	[1]
Asthma	CA23	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 9811353
  CAS Number: CAS 187269-40-5
  TTD Drug ID: DM0TH9A

Molecule-Related Drug Atlas

Drug(s) Targeting E-selectin (SELE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GMI-1070	DMJ432G	Asthma	CA23	Phase 3	[3]
GMI-1271	DMDTGWQ	Acute myeloid leukaemia	2A60	Phase 3	[4]
CY-1503	DML906E	Hypertension	BA00-BA04	Phase 2/3	[5]
GMI-1359	DML1KSA	Breast cancer	2C60-2C65	Phase 1	[6]
PF-07209326	DM7YRAL	Sickle-cell disorder	3A51	Phase 1	[7]
GI-270384X	DM3KN2Q	Inflammatory bowel disease	DD72	Terminated	[8]
Fucose	DMAHMSV	N. A.	N. A.	Investigative	[9]
O-Sialic Acid	DMCAR7B	Discovery agent	N.A.	Investigative	[10]
Efomycine M	DMOKX76	Discovery agent	N.A.	Investigative	[11]
1na	DM0A1YI	Discovery agent	N.A.	Investigative	[9]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
E-selectin (SELE)	TTAU4D6	LYAM2_HUMAN	Inhibitor	[2]

References

• [1] Emerging drugs for asthma. Expert Opin Emerg Drugs. 2008 Dec;13(4):643-53.
• [2] Effects of the pan-selectin antagonist bimosiamose (TBC1269) in experimental human endotoxemia. Shock. 2008 Apr;29(4):475-82.
• [3] Deal watch: Pfizer deal for selectin inhibitor highlights potential of glycomimetic drugs. Nat Rev Drug Discov. 2011 Dec 1;10(12):890.
• [4] Clinical pipeline report, company report or official report of glycomimetics.
• [5] Adjunctive selectin blockade successfully reduces infarct size beyond thrombolysis in the electrolytic canine coronary artery model. Circulation. 1995 Aug 1;92(3):492-9.
• [6] Clinical pipeline report, company report or official report of GlycoMimetics.
• [7] ClinicalTrials.gov (NCT04255875) A RANDOMIZED, DOUBLE-BLIND, PLACEBO CONTROLLED EVALUATION OF SINGLE DOSES OF PF-07209326 IN HEALTHY PARTICIPANTS (SAFETY, TOLERABILITY, AND PHARMACOKINETICS [PK]) FOLLOWED BY AN OPEN LABEL, REPEAT DOSE EVALUATION IN SICKLE CELL DISEASE PARTICIPANTS (SAFETY, TOLERABILITY, PK AND EFFICACY). U.S.National Institutes of Health.
• [8] Inhibition of endothelial cell adhesion molecule expression improves colonic hyperalgaesia. Neurogastroenterol Motil. 2009 Feb;21(2):189-96.
• [9] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [10] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [11] Interfering with leukocyte rolling--a promising therapeutic approach in inflammatory skin disorders Trends Pharmacol Sci. 2003 Feb;24(2):49-52.