Details of the Drug-Related molecule(s) Interaction Atlas

US9475795, 80 Drug Info

SCHEMBL15548679; CHEMBL3891242; RXIULEDXXPGKEE-UHFFFAOYSA-N; BDBM250601; US9475795, 80; 4-(4-Chloro-2-fluorobenzyl)-1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)-4-fluoropiperidine

Cross-matching ID

PubChem CID

72550891

TTD Drug ID

DM0ZDL3

General Information of Drug (ID: DM0ZDL3)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting Prokineticin receptor-1 (PROKR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ZINC19658740	DMLZDAK	N. A.	N. A.	Patented	[2]
US9475795, 89	DMR6ODL	N. A.	N. A.	Patented	[1]
US9475795, 19	DMGPDEF	N. A.	N. A.	Patented	[1]
triazine compound PC10	DMCLA2D	Discovery agent	N.A.	Investigative	[3]
IS1	DMNF70P	Discovery agent	N.A.	Investigative	[4]
IS20	DMQ5GA9	Discovery agent	N.A.	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prokineticin receptor-1 (PROKR1)	TTB9CIL	PKR1_HUMAN	Inhibitor	[1]

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References

1	Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases. US9475795.
2	Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases. US10167273.
3	Prokineticin receptor 1 antagonist PC-10 as a biomarker for imaging inflammatory pain. J Nucl Med. 2011 Apr;52(4):600-7.
4	Discovery and cardioprotective effects of the first non-Peptide agonists of the G protein-coupled prokineticin receptor-1. PLoS One. 2015 Apr 1;10(4):e0121027.