Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTB9CIL)

DTT Name Prokineticin receptor-1 (PROKR1)
Synonyms Prokineticin receptor 1; PROKR1; Gprotein coupled receptor ZAQ; Gprotein coupled receptor 73; GPR73a
Gene Name PROKR1
DTT Type
Patented-recorded target
 [1]
BioChemical Class
GPCR rhodopsin
UniProt ID
PKR1_HUMAN
TTD ID
T85115
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
METTMGFMDDNATNTSTSFLSVLNPHGAHATSFPFNFSYSDYDMPLDEDEDVTNSRTFFA
AKIVIGMALVGIMLVCGIGNFIFIAALVRYKKLRNLTNLLIANLAISDFLVAIVCCPFEM
DYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTAT
GLIALVWTVSILIAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGIE
FVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPF
YGFTIVRDFFPTVFVKEKHYLTAFYIVECIAMSNSMINTLCFVTVKNDTVKYFKKIMLLH
WKASYNGGKSSADLDLKTIGMPATEEVDCIRLK
Function
Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy.
Reactome Pathway
G alpha (q) signalling events (R-HSA-416476 )
Peptide ligand-binding receptors (R-HSA-375276 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
4 Patented Agent(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
US9475795, 19 DMGPDEF N. A. N. A. Patented [2]
US9475795, 80 DM0ZDL3 N. A. N. A. Patented [2]
US9475795, 89 DMR6ODL N. A. N. A. Patented [2]
ZINC19658740 DMLZDAK N. A. N. A. Patented [3]
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3 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
IS1 DMNF70P Discovery agent N.A. Investigative [1]
IS20 DMQ5GA9 Discovery agent N.A. Investigative [1]
triazine compound PC10 DMCLA2D Discovery agent N.A. Investigative [4]
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References

1 Discovery and cardioprotective effects of the first non-Peptide agonists of the G protein-coupled prokineticin receptor-1. PLoS One. 2015 Apr 1;10(4):e0121027.
2 Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases. US9475795.
3 Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases. US10167273.
4 Prokineticin receptor 1 antagonist PC-10 as a biomarker for imaging inflammatory pain. J Nucl Med. 2011 Apr;52(4):600-7.