Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1G4S9)

Drug Name

Sodium Phosphate, Dibasic, Anhydrous Drug Info

Synonyms

7558-79-4; DISODIUM PHOSPHATE; Disodium hydrogen phosphate; Disodium hydrogenorthophosphate; Sodium phosphate dibasic; Acetest; Soda phosphate; Disodium orthophosphate; Sodium hydrogenphosphate; Sodium hydrogen phosphate; Phosphoric acid, disodium salt; Disodium acid phosphate; Phosphate of soda; sec-Sodium phosphate; Disodium acid orthophosphate; Sodium monohydrogen phosphate; Caswell No. 778; Disodium hydrophosphate; Disodium monohydrogen phosphate; Disodium phosphoric acid; FEMA Number 2398

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 24203
ChEBI ID: CHEBI:34683
CAS Number: CAS 7558-79-4
TTD Drug ID: DM1G4S9
INTEDE Drug ID: DR0004

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

Drug Status:

Approved Drug(s)

Discontinued Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Metabolized By Steroid 17-alpha-monooxygenase (CYP17A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[3]
Aminophenazone	DMY2AH1	Anaesthesia	9A78.6	Phase 4	[4]
Dexniguldipine	DMLZIT2	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 2	[5]
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Drug(s) Targeting Carbonic anhydrase IV (CA-IV)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Seborrhoeic dermatitis	EA81	Approved	[6]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[7]
Brinzolamide	DMBAPFG	Open-angle glaucoma	9C61	Approved	[8]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[9]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[10]
Phenol	DM1QSM3	N. A.	N. A.	Phase 2/3	[9]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[11]
Sodium pyruvate	DMST6A3	Asthma	CA23	Phase 1/2	[12]
SULFAMIDE	DMMAS3K	N. A.	N. A.	Phase 1	[13]
Ferulic Acid	DMJC7NF	Discovery agent	N.A.	Patented	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase IV (CA-IV)	TTZHA0O	CAH4_HUMAN	Inhibitor	[1]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Steroid 17-alpha-monooxygenase (CYP17A1)^{Main DME}	DEX2KIA	CP17A_HUMAN	Substrate	[2]

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References

1	Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral dru... Bioorg Med Chem Lett. 2004 Dec 6;14(23):5763-7.
2	Transcriptional complexes at the CYP17 CRS. Endocr Res. 2002 Nov;28(4):551-8.
3	Identifying susceptibility genes for prostate cancer--a family-based association study of polymorphisms in CYP17, CYP19, CYP11A1, and LH-beta. Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):2035-9.
4	Contribution of human hepatic cytochrome P450s and steroidogenic CYP17 to the N-demethylation of aminopyrine. Xenobiotica. 1999 Feb;29(2):187-93.
5	In vitro metabolism of dexamethasone (DEX) in human liver and kidney: the involvement of CYP3A4 and CYP17 (17,20 LYASE) and molecular modelling studies. Biochem Pharmacol. 1997 Sep 1;54(5):605-11.
6	Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8.
7	Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1149-54.
8	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
9	Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3.
10	Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164.
11	Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-r... Bioorg Med Chem Lett. 2008 Aug 1;18(15):4282-6.
12	Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. Bioorg Med Chem Lett. 2005 Feb 1;15(3):573-8.
13	Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mamm... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3601-5.