Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1MGBX)

Drug Name

Alpha-Helical lipopeptides IIS Drug Info

Synonyms

IIS

Indication

Disease Entry	ICD 11	Status	REF
Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[1]

Therapeutic Class

Antiviral Agents

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting MERS-CoV spike glycoprotein (S)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nafamostat	DMU1XOD	Pancreatitis	DC31-DC34	Approved	[2]
REGN 3048	DMW08TD	Middle East Respiratory Syndrome (MERS)	1D64	Discontinue in Phase 1 Trial	[3]
REGN 3051	DMLH28J	Middle East Respiratory Syndrome (MERS)	1D64	Discontinue in Phase 1 Trial	[3]
PMID26911565-peptide-P9	DMUH012	Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[4]
MERS-five-helix bundle	DMG5YRP	Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[5]
Alpha-Helical lipopeptides LLS	DM3WVM4	Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[1]
Peptide P21S10	DMMWQTI	Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[6]
Alpha-Helical lipopeptides IIK	DMVSKQF	Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[1]
Alpha-Helical lipopeptides FFS	DMATQB7	Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[1]
------------------------------------------------------------------------------------


⏷ Show the Full List of 9 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
MERS-CoV spike glycoprotein (S)	TT85VHW	A0A140AYZ5_9BETC	Inhibitor	[1]

------------------------------------------------------------------------------------

References

1	De Novo Design of -Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery. J Med Chem. 2018 Oct 11;61(19):8734-8745.
2	Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay Antimicrob Agents Chemother. 2016 Oct 21;60(11):6532-6539.
3	Pre- And Postexposure Efficacy of Fully Human Antibodies Against Spike Protein in a Novel Humanized Mouse Model of MERS-CoV Infection. Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8738-43. doi: 10.1073/pnas.1510830112.
4	A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses. Sci Rep. 2016 Feb 25;6:22008.
5	Identification of a Novel Inhibitor against Middle East Respiratory Syndrome Coronavirus. Viruses. 2017 Sep 14;9(9). pii: E255.
6	Discovery of Hydrocarbon-Stapled Short -Helical Peptides as Promising Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Fusion Inhibitors. J Med Chem. 2018 Mar 8;61(5):2018-2026.