Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1N7AG)

Drug Name

N-(thiazol-2-yl)benzamide Drug Info

Synonyms

N-(1,3-Thiazol-2-yl)benzamide; N-Thiazol-2-yl-benzamide; SCQBDADQAVXTMZ-UHFFFAOYSA-N; 13053-82-2; N-(thiazol-2-yl)benzamide; Benzamide, N-2-thiazolyl-; AC1LC4SL; AC1Q5LQU; n-thiazol-2-yl benzamide; N-(2-Thiazolyl)benzamide; MLS000711892; SCHEMBL995829; CHEMBL90846; Benzamide, N-(2-thiazolyl)-; IFLab1_003538; ZINC39994; MolPort-000-557-753; HMS1422A18; HMS2643F11; N-(1,3-Thiazol-2-yl)benzamide #; STK018313; AKOS005145274; AKOS000638160; MCULE-9395155160; IDI1_009645; SMR000281659; phenyl-N-(1,3-thiazol-2-yl)carboxamide; BAS 00332640

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 569547
CAS Number: CAS 13053-82-2
TTD Drug ID: DM1N7AG

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting LOX-5 messenger RNA (ALOX5 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TEBUFELONE	DMMUE8P	Pain	MG30-MG3Z	Discontinued in Phase 2	[2]
ZD-2138	DMVFCX7	Asthma	CA23	Discontinued in Phase 2	[3]
BW A4C	DMNUMDG	Arthritis	FA20	Terminated	[4]
KAEMPFEROL	DMHEMUB	Discovery agent	N.A.	Investigative	[5]
2,4'-Dimethoxy-5,3'-di-(2-propenyl)-biphenyl	DMWNJ84	Discovery agent	N.A.	Investigative	[6]
METHYLHONOKIOL	DM9YE6K	Discovery agent	N.A.	Investigative	[6]
HONOKIOL	DMJWT3X	Discovery agent	N.A.	Investigative	[6]
PUUPEHEDIONE	DMF28IU	Discovery agent	N.A.	Investigative	[7]
PUUPEHENONE	DMF3BCK	Discovery agent	N.A.	Investigative	[7]
Isojaspic acid	DMHTBDN	Discovery agent	N.A.	Investigative	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
LOX-5 messenger RNA (ALOX5 mRNA)	TTSJ6Q4	LOX5_HUMAN	Inhibitor	[1]

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References

1	Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening. J Med Chem. 2007 May 31;50(11):2640-6.
2	New cyclooxygenase-2/5-lipoxygenase inhibitors. 3. 7-tert-butyl-2, 3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflam... J Med Chem. 1998 Aug 27;41(18):3515-29.
3	Synthesis and biological activity of N-aroyl-tetrahydro-gamma-carbolines. Bioorg Med Chem. 2010 Jun 1;18(11):3910-24.
4	Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid. J Med Chem. 2008 Sep 11;51(17):5449-53.
5	Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti. J Nat Prod. 2007 May;70(5):859-62.
6	Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxyge... Bioorg Med Chem. 2009 Jul 1;17(13):4459-65.
7	Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. J Nat Prod. 2009 Oct;72(10):1857-63.