Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1O3BY)

• Drug Name: Mecasermin Drug Info
• Synonyms: Increlex (TN)

Indication

Disease Entry	ICD 11	Status	REF
Growth failure	LD2F.1Y	Approved	[1] , [2]

• Therapeutic Class: Immunomodulatory Agents
• Cross-matching ID: TTD Drug ID: DM1O3BY

Molecule-Related Drug Atlas

Drug(s) Targeting Insulin-like growth factor I receptor (IGF1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Teprotumumab	DM4L59B	Graves disease	5A02.0	Approved	[7]
Somatomedin-1	DMZ9FAO	Hormone deficiency	5A61.1	Approved	[2]
OSI-906	DMHKZLF	Solid tumour/cancer	2A00-2F9Z	Phase 3	[8]
Rinfabate	DML9FD4	Solid tumour/cancer	2A00-2F9Z	Phase 2/3	[9]
MM-141	DM2RJ4D	Pancreatic cancer	2C10	Phase 2	[10]
TT-100	DMZE6Y9	Non-small-cell lung cancer	2C25.Y	Phase 2	[11]
AMG 479	DM0DRAZ	Breast cancer	2C60-2C65	Phase 2	[12]
VPI-2690B	DMUQZT4	Diabetic nephropathy	GB61.Z	Phase 2	[13]
AXL-1717	DMTQ1Y3	Solid tumour/cancer	2A00-2F9Z	Phase 2	[14]
R1507	DMIUS5X	Graves ophthalmopathy	9C82.3	Phase 2	[15]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Insulin-like growth factor I receptor (IGF1R)	TTHRID2	IGF1R_HUMAN	Inhibitor	[3] , [4] , [5] , [6]

References

• [1] Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
• [2] 2005 approvals: Safety first. Nature Reviews Drug Discovery 5, 92-93 (February 2006).
• [3] IGF-1R, IGF-1 and IGF-2 expression as potential prognostic and predictive markers in colorectal-cancer. Virchows Arch. 2003 Aug;443(2):139-45.
• [4] One of two chondrocyte-expressed isoforms of cartilage intermediate-layer protein functions as an insulin-like growth factor 1 antagonist. Arthritis Rheum. 2003 May;48(5):1302-14.
• [5] Analysis of the human type I insulin-like growth factor receptor promoter region. Biochem Biophys Res Commun. 1991 Jun 28;177(3):1113-20.
• [6] Insulin-like growth factor I receptor gene structure. J Biol Chem. 1992 May 25;267(15):10759-63.
• [7] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
• [8] Imidazo[2,1-b]thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family... Bioorg Med Chem Lett. 2010 Apr 15;20(8):2452-5.
• [9] Mecasermin rinfabate: insulin-like growth factor-I/insulin-like growth factor binding protein-3, mecaserimin rinfibate, rhIGF-I/rhIGFBP-3. Drugs R D. 2005;6(2):120-7.
• [10] MM-141, an IGF-IR- and ErbB3-directed bispecific antibody, overcomes network adaptations that limit activity of IGF-IR inhibitors. Mol Cancer Ther. 2014 Feb;13(2):410-25.
• [11] BiPar Sciences Co-founder Reunites Management Team At TriAct Therapeutics to Advance Clinical Stage Cancer Programs. TriAct Therapeutics. Sept. 10, 2009.
• [12] Clinical pipeline report, company report or official report of Amgen (2009).
• [13] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [14] Clinical Phase I study with an Insulin-like Growth Factor-1 receptor inhibitor: experiences in patients with squamous non-small cell lung carcinoma. Acta Oncol. 2011 Apr;50(3):441-7.
• [15] Clinical pipeline report, company report or official report of Roche (2009).