Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1TKG4)

Drug Name

RDEA3170 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Hyperuricaemia	5C55.Y	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Urate anion exchanger 1 (URAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lesinurad	DMUR64T	Hyperuricaemia	5C55.Y	Approved	[3]
Dotinurad	DM0UPQJ	Gout	FA25	Phase 3	[4]
URC102	DMY89BN	Gout	FA25	Phase 2	[5]
RDEA-684	DMNWYHD	Gout	FA25	Phase 2	[3]
AR882	DMFGYZ8	Gout	FA25	Phase 2	[6]
Sulfonamide derivative 11	DMJBR86	N. A.	N. A.	Patented	[7]
Cycloalkyl acid derivative 1	DMXMGSP	N. A.	N. A.	Patented	[7]
2-ethyl-3-(4-hydroxy) benzoyl benzofuran derivative 1	DMHYIAV	N. A.	N. A.	Patented	[7]
Tihoacetate derivative 1	DM6QHO0	N. A.	N. A.	Patented	[7]
Cycloalkyl acid derivative 2	DM09LY3	N. A.	N. A.	Patented	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	ClinicalTrials.gov (NCT02078219) Phase II Dose Finding Study of RDEA3170 Versus Placebo in Japanese Patients With Gout or Asymptomatic Hyperuricemia. U.S. National Institutes of Health.
2	The pathophysiology of hyperuricaemia and its possible relationship to cardiovascular disease, morbidity and mortality. BMC Nephrol. 2013; 14: 164.
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1031).
4	Dotinurad: a novel selective urate reabsorption inhibitor for the treatment of hyperuricemia and gout. Expert Opin Pharmacother. 2021 Aug;22(11):1397-1406.
5	Clinical pipeline report, company report or official report of Chugai Pharmaceutical (2013).
6	Clinical pipeline report, company report or official report of Arthrosi Therapeutics
7	Urate transporter URAT1 inhibitors: a patent review (2012 - 2015).Expert Opin Ther Pat. 2016 Jul 30:1-10.