Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1YB0R)

Drug Name

OZ277 Drug Info

Synonyms

Arterolane; UNII-3N1TN351VB; 664338-39-0; OZ277; 3N1TN351VB; OZ-277; C22H36N2O4; Arterolane [INN]; RBx11160; OZ 277; SCHEMBL4547841; CHEMBL404431; CHEMBL580910; CHEMBL221773; SCHEMBL12612733; CHEMBL1197433; SCHEMBL13951812; SCHEMBL11379522; SCHEMBL10307589; VXYZBLXGCYNIHP-BBMJWGJISA-N; VXYZBLXGCYNIHP-CAGINOIPSA-N; ZINC14191464; RBX-11160; NCGC00274173-01; HY-10852; Y1261

Indication

Disease Entry	ICD 11	Status	REF
Malaria	1F40-1F45	Approved	[1]

Cross-matching ID

PubChem CID: 10475633
ChEBI ID: CHEBI:136054
CAS Number: CAS 664338-39-0
TTD Drug ID: DM1YB0R

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Preclinical Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Sarcoplasmic/endoplasmic reticulum calcium ATPase (ATP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[1]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[1]
Piperaquine	DMT70RC	Malaria	1F40-1F45	Approved	[1]
Artemisinin SP	DMFETDK	Malaria	1F40-1F45	Approved	[1]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[1]
Pyronaridine	DMUWAM2	Malaria	1F40-1F45	Approved	[1]
Vanadate	DMQL0KF	Psoriatic arthritis	FA21	Phase 3	[2]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[3]
Cyclopiazonic acid	DMPJ08G	Discovery agent	N.A.	Investigative	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Sarcoplasmic/endoplasmic reticulum calcium ATPase (ATP2A)	TTZVSJ2	NOUNIPROTAC	Inhibitor	[1]

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References

1	The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
2	Expression and functional characterization of a Plasmodium falciparum Ca2+-ATPase (PfATP4) belonging to a subclass unique to apicomplexan organisms. J Biol Chem. 2001 Apr 6;276(14):10782-7.
3	Elucidation of the topography of the thapsigargin binding site in the sarco-endoplasmic calcium ATPase. Bioorg Med Chem. 2010 Aug 1;18(15):5634-46.