Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM27H0P)

Drug Name

Collategene Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Peripheral Ischemic Ulcers	BD41	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Hepatocyte growth factor (HGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
VM-202	DMSW80U	Angina pectoris	BA40	Phase 3	[3]
Donaperminogene seltoplasmid	DMH8IT5	Diabetic foot ulcer	BD54	Phase 3	[4]
ANG-3777	DMGP8WX	Delayed graft function	4B24.0	Phase 3	[5]
Ficlatuzumab	DMG65WH	Multiple myeloma	2A83	Phase 2	[6]
MP0250	DMR3VCY	Non-small-cell lung cancer	2C25.Y	Phase 1/2	[6]
ABI-011	DM1KD7U	Lymphoma	2A80-2A86	Phase 1	[6]
TAK-701	DML3M0O	Advanced malignancy	2A00-2F9Z	Phase 1	[7]
Rilotumumab	DMD8ZSW	Grade IV malignant glioma	2A00.0	Discontinued in Phase 2	[8]
N,O6-Disulfo-Glucosamine	DMYCV7U	Discovery agent	N.A.	Investigative	[9]
O2-Sulfo-Glucuronic Acid	DME78MS	Discovery agent	N.A.	Investigative	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Hepatocyte growth factor (HGF)	TT4V2JM	HGF_HUMAN	Not Available	[2]

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References

1	ClinicalTrials.gov (NCT04267640) A Phase II Double-Blind, Randomized, Placebo-Controlled Study to Assess the Efficacy and Safety of AMG0001 to Improve Ulcer Healing and Perfusion in Subjects Who Have Peripheral Ischemic Ulcers of the Lower Extremity. U.S.National Institutes of Health.
2	Randomized, double-blind, placebo-controlled clinical trial of hepatocyte growth factor plasmid for critical limb ischemia. Gene Ther. 2010 Sep;17(9):1152-61.
3	Therapeutic angiogenesis using naked DNA expressing two isoforms of the hepatocyte growth factor in a porcine acute myocardial infarction model. Eur J Cardiothorac Surg. 2008 Oct;34(4):857-63.
4	Clinical pipeline report, company report or official report of ViroMed.
5	Hepatocyte Growth Factor Mimetic ANG-3777 for Cardiac Surgery-Associated Acute Kidney Injury. Kidney Int Rep. 2020 Sep 25;5(12):2325-2332.
6	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
7	Targeting MET in cancer: rationale and progress.Nat Rev Cancer.2012 Jan 24;12(2):89-103.
8	Clinical pipeline report, company report or official report of Amgen (2009).
9	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.