Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2UMGE)

Drug Name

Ad5-TRAIL Drug Info

Synonyms

Ad5-TRAIL adenoviral gene therapy (prostate cancer), University of Iowa

Indication

Disease Entry	ICD 11	Status	REF
Prostate cancer	2C82.0	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting TNF related apoptosis inducing ligand (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DA-3607	DM4JG0B	Brain cancer	2A00	Phase 1	[3]
ABBV-621	DM90EO3	Haematological malignancy	2B33.Y	Phase 1	[4]
Nimesulide	DMR1NMD	Metastatic colorectal cancer	2B91	Terminated	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
TNF related apoptosis inducing ligand (TNFSF10)	TTA5MS9	TNF10_HUMAN	Modulator	[2]

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References

1	Phase I trial of Ad5-TRAIL-mediated gene transfer in men with locally-confined prostate cancer prior to planned radical prostatectomy. The Journal of Urology. 04/2008; 179(4):396-396.
2	Enhancement of Ad5-TRAIL cytotoxicity against renal cell carcinoma with histone deacetylase inhibitors. Cancer Gene Ther. 2006 Jun;13(6):628-32.
3	Cancer gene therapy using a novel secretable trimeric TRAIL. Gene Ther. 2006 Feb;13(4):330-8.
4	Clinical pipeline report, company report or official report of AbbVie.
5	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.