Details of the Drug

General Information of Drug (ID: DM2UMGE)

Drug Name

Ad5-TRAIL

Synonyms

Ad5-TRAIL adenoviral gene therapy (prostate cancer), University of Iowa

Indication

Disease Entry	ICD 11	Status	REF
Prostate cancer	2C82.0	Phase 1	[1]
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Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
TNF related apoptosis inducing ligand (TNFSF10)	TTA5MS9	TNF10_HUMAN	Modulator	[2]

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Molecular Interaction Atlas (MIA)

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Molecular Expression Atlas of This Drug

The Studied Disease

Prostate cancer

ICD Disease Classification

2C82.0

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
TNF related apoptosis inducing ligand (TNFSF10)	DTT	TNFSF10	4.40E-01	-0.16	-0.18

Molecular Expression Atlas (MEA)

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References

1	Phase I trial of Ad5-TRAIL-mediated gene transfer in men with locally-confined prostate cancer prior to planned radical prostatectomy. The Journal of Urology. 04/2008; 179(4):396-396.
2	Enhancement of Ad5-TRAIL cytotoxicity against renal cell carcinoma with histone deacetylase inhibitors. Cancer Gene Ther. 2006 Jun;13(6):628-32.