Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3MXT8)

Drug Name

BI 201335 Drug Info

Synonyms

Faldaprevir; BI-201335; UNII-958X4J301A; CHEMBL1241348; 958X4J301A; N-[(Cyclopentyloxy)carbonyl]-3-Methyl-L-Valyl-(4r)-4-[(8-Bromo-7-Methoxy-2-{2-[(2-Methylpropanoyl)amino]-1,3-Thiazol-4-Yl}quinolin-4-Yl)oxy]-N-[(1r,2s)-1-Carboxy-2-Ethenylcyclopropyl]-L-Prolinamide; BI 201335; 801283-95-4; BI201335; Faldaprevir [USAN:INN]; SCHEMBL222429; BDBM50336545; SB16712; DB11808

Indication

Disease Entry	ICD 11	Status	REF
Hepatitis C virus infection	1E51.1	Phase 3	[1]

Cross-matching ID

PubChem CID: 42601552
CAS Number: CAS 801283-95-4
TTD Drug ID: DM3MXT8
VARIDT Drug ID: DR00990

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Human immunodeficiency virus Protease (HIV PR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Saquinavir	DMG814N	Human immunodeficiency virus infection	1C62	Approved	[2]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[3]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[4]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[5]
Amprenavir	DMLMXE0	Human immunodeficiency virus infection	1C62	Approved	[6]
Darunavir	DMN3GCH	Human immunodeficiency virus infection	1C62	Approved	[7]
Tipranavir	DM8HJX6	Human immunodeficiency virus infection	1C62	Approved	[8]
Fosamprenavir	DM4W9B3	Human immunodeficiency virus infection	1C62	Approved	[9]
BMS 650032	DMQI43G	Hepatitis C virus infection	1E51.1	Phase 2	[10]
Danoprevir	DM20MDU	Hepatitis C virus infection	1E51.1	Phase 2	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Human immunodeficiency virus Protease (HIV PR)	TT5FNQT	POL_HV1B1	Inhibitor	[1]

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References

1	2011 Pipeline of Boehringer Ingelheim Pharma.
2	PL-100, a novel HIV-1 protease inhibitor displaying a high genetic barrier to resistance: an in vitro selection study. J Med Virol. 2008 Dec;80(12):2053-63.
3	Quantification of HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors in peripheral blood mononuclear cell lysate using liq... J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Feb 15;877(5-6):575-80.
4	Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV. Int J Antimicrob Agents. 2009 Apr;33(4):307-20.
5	Hollow-fiber unit evaluation of a new human immunodeficiency virus type 1 protease inhibitor, BMS-232632, for determination of the linked pharmacod... J Infect Dis. 2001 Apr 1;183(7):1126-9.
6	Darunavir: a review of its use in the management of HIV infection in adults. Drugs. 2009;69(4):477-503.
7	2006 drug approvals: finding the niche. Nat Rev Drug Discov. 2007 Feb;6(2):99-101.
8	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
9	Fosamprenavir/ritonavir in advanced HIV disease (TRIAD): a randomized study of high-dose, dual-boosted or standard dose fosamprenavir/ritonavir in ... J Antimicrob Chemother. 2009 Aug;64(2):398-410.
10	2011 Pipeline of Bristol-Myers Squibb.
11	2011 Pipeline of InterMune.