Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3PMAZ)

Drug Name
GW-3333 Drug Info
Synonyms
SMZPWUUYPYYHIV-HNJRGHQBSA-N; GW3333; CHEMBL514958; UNII-54J77T5T74; 54J77T5T74; 212609-68-2; AC1Q5NWC; AC1L50QR; BIDD:PXR0031; n2-[(2r,3s)-3-[formyl(hydroxy)amino]-4-methyl-2-(2-methylpropyl)pentanoyl]-n-pyridin-2-yl-l-isoleucinamide; SCHEMBL2875070; BDBM50247805; (2R,3S)-3-[formyl(hydroxy)amino]-4-methyl-N-[(2S,3S)-3-methyl-1-oxo-1-(pyridin-2-ylamino)pentan-2-yl]-2-(2-methylpropyl)pentanamide; (2R,3S)-3-(Formyl-hydroxyamino)-2-(2-methyl-1-propyl)-4-methylpentanoic acid, ((1S,2S)-2-methyl-1-(2-pyridylcarbamoyl)-1-butyl)amide; GW3333; Gw 3333; N2-[(2r,3s)-3-[formyl(hydroxy)amino]-4-methyl-2-(2-methylpropyl)pentanoyl]-n-pyridin-2-yl-l-isoleucinamide; 5-carboxymethylthio-3-(3'-chlorophenyl)-1,2,4-oxadiazol
Indication
Disease Entry ICD 11 Status REF
Chronic obstructive pulmonary disease CA22 Preclinical [1]
Cross-matching ID
PubChem CID
216470
CAS Number
CAS 212609-68-2
TTD Drug ID
DM3PMAZ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Investigative Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Bacterial Cystathionine gamma-synthase (Bact metB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
N'-Pyridoxyl-Lysine-5'-Monophosphate DM3ZHBO Discovery agent N.A. Investigative [3]
Drug(s) Targeting TNF alpha converting enzyme (ADAM17)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Apratastat DM8W4N9 Rheumatoid arthritis FA20 Phase 2 [4]
Aderbasib DMYOMSC Breast cancer 2C60-2C65 Phase 1/2 [5]
DPC-333 DM4JBQD Inflammatory bowel disease DD72 Terminated [1]
IK-862 DMJA4UE Discovery agent N.A. Investigative [6]
SR-973 DMU48OD Discovery agent N.A. Investigative [7]
SL422 DM3I2US Discovery agent N.A. Investigative [8]
PKF-242-484 DMNDLAS Discovery agent N.A. Investigative [9]
N-hydroxy-3-(2-oxo-2H-chromen-3-yl)propanamide DMWXUCT Discovery agent N.A. Investigative [10]
N-hydroxy-3-(6-methoxy-2-oxo-2H-chromen-3-yl) DMA6EPH Discovery agent N.A. Investigative [10]
PKF-241-466 DM04C9V Discovery agent N.A. Investigative [9]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bacterial Cystathionine gamma-synthase (Bact metB) TTDU0HP METB_ECOLI Inhibitor [2]
TNF alpha converting enzyme (ADAM17) TT6AZXG ADA17_HUMAN Inhibitor [1]

References

1 Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91.
2 Crystal structures of cystathionine gamma-synthase inhibitor complexes rationalize the increased affinity of a novel inhibitor. J Mol Biol. 2001 Aug 24;311(4):789-801.
3 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
4 Acetylenic TACE inhibitors. Part 3: Thiomorpholine sulfonamide hydroxamates. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1605-9.
5 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
6 Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. Bioorg Med Chem. 2008 Oct 1;16(19):8781-94.
7 Synthesis and evaluation of succinoyl-caprolactam gamma-secretase inhibitors. Bioorg Med Chem Lett. 2006 May 1;16(9):2357-63.
8 Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo. J Med Chem. 2001 Aug 2;44(16):2636-60.
9 Current perspective of TACE inhibitors: a review. Bioorg Med Chem. 2009 Jan 15;17(2):444-59.
10 Chromen-based TNF-alpha converting enzyme (TACE) inhibitors: design, synthesis, and biological evaluation. Bioorg Med Chem. 2008 Jan 1;16(1):530-5.