General Information of Drug (ID: DM3TH6Y)

Drug Name
CBP-307 Drug Info
Synonyms CBP-307; CBP 307; CBP307; BCP20840; AKOS040748092
Indication
Disease Entry ICD 11 Status REF
Ulcerative colitis DD71 Phase 2 [1]
Cross-matching ID
PubChem CID
139266790
TTD Drug ID
DM3TH6Y

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Siponimod DM2R86O Multiple sclerosis 8A40 Approved [3]
Fingolimod DM5JVAN Multiple sclerosis 8A40 Approved [4]
Ozanimod DMT6AM2 Multiple sclerosis 8A40 Approved [5]
Etrasimod DMT0A3Y Ulcerative colitis DD71 Approved [6]
Ponesimod DMEAOYJ Multiple sclerosis 8A40 Approved [7]
MT-1303 DMSE9TH Crohn disease DD70 Phase 2 [8]
ONO-4641 DMLUM3Y Rheumatoid arthritis FA20 Phase 2 [9]
KRP-203 DMOW9X2 Cutaneous lupus erythematosus EB5Z Phase 2 [9]
VTX-002 DMZ8Z5A Ulcerative colitis DD71 Phase 2 [10]
Sphingosine-1-phosphate DMJCQKA Acne vulgaris ED80 Phase 1 [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Sphingosine-1-phosphate receptor 1 (S1PR1) TT9JZCK S1PR1_HUMAN Agonist [2]

References

1 ClinicalTrials.gov (NCT04700449) A Multicenter, Randomized, Double-blind, Placebo-controlled Phase II Clinical Trial to Evaluate the Efficacy and Safety of CBP-307 in Subjects With Moderate to Severe Ulcerative Colitis (UC). U.S.National Institutes of Health.
2 Clinical pipeline report, company report or official report of Connect Biopharma
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
4 Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
6 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
7 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2021
8 Sphingosine 1-Phosphate Receptor Modulators in Multiple Sclerosis. CNS Drugs. 2015 Jul;29(7):565-75.
9 Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond. Nat Rev Drug Discov. 2013 Sep;12(9):688-702.
10 Clinical pipeline report, company report or official report of Ventyx Biosciences
11 Exploration of amino alcohol derivatives as novel, potent, and highly selective sphingosine-1-phosphate receptor subtype-1 agonists. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2520-4.