Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3TPY8)

Drug Name

Interferon Alfa-2b, Recombinant Drug Info

Synonyms

Alpharona (TN); Genferon (TN); Gerpferon (TN); Grippferon (TN); Infagel (TN); Intron A (TN); Kipferon (TN); Realderon (TN); Recolin (TN); Teva (TN); Viferon (TN)

Indication

Disease Entry	ICD 11	Status	REF
Hairy cell leukaemia	2A82.2	Approved	[1]

Therapeutic Class

Anticancer Agents

Cross-matching ID

PubChem CID: 71306834
TTD Drug ID: DM3TPY8

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Interferon alpha/beta receptor 2 (IFNAR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Interferon alfa-n1	DM4AK0Q	Chronic myelogenous leukaemia	2A20.0	Approved	[3]
Sifalimumab	DM1BS03	Renal cell carcinoma	2C90	Approved	[4]
Interferon beta-1b	DMCN61Z	Multiple sclerosis	8A40	Approved	[5]
Anifrolumab	DM3FPAQ	Systemic lupus erythematosus	4A40.0	Approved	[6]
Interferon alfacon-1	DM90WJH	Hepatitis C	1E51	Approved	[7]
Alfa-interferon	DMXMK5S	Endometriosis	GA10	Phase 1	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interferon alpha/beta receptor 2 (IFNAR2)	TTMQB37	INAR2_HUMAN	Binder	[2]

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References

1	Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
2	Successful treatment of relapsed Philadelphia chromosome-positive acute lymphoblastic leukemia with T315I mutation after haplo-identical hematopoie... Leuk Res. 2009 Aug;33(8):e111-3.
3	Lymphoblastoid interferon alfa-n1 improves the long-term response to a 6-month course of treatment in chronic hepatitis C compared with recombinant interferon alfa-2b: results of an international randomized controlled trial. Clinical Advisory Group for the Hepatitis C Comparative Study. Hepatology. 1998 Apr;27(4):1121-7.
4	Clinical pipeline report, company report or official report of AstraZeneca (2009).
5	Interferon-beta(1b) Treatment in Neuromyelitis Optica. Eur Neurol. 2009 Jul 7;62(3):167-170.
6	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
7	Retreating chronic hepatitis C with daily interferon alfacon-1/ribavirin after nonresponse to pegylated interferon/ribavirin: DIRECT results. Hepatology. 2009 Jun;49(6):1838-46.
8	New drugs in development for the treatment of endometriosis. Expert Opin Investig Drugs. 2008 Aug;17(8):1187-202.