General Information of Drug (ID: DM42BGX)

Drug Name
L-689065 Drug Info
Synonyms
CHEMBL295761; L-689065; SCHEMBL9581325; BDBM50045667; 3-[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-2,2-dimethyl-propionic acid; 3-[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-3-thia-1-aza-acenaphthylen-2-yl]-2,2-dimethyl-propionic acid
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
9960281
TTD Drug ID
DM42BGX

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Discontinued Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
TEBUFELONE DMMUE8P Pain MG30-MG3Z Discontinued in Phase 2 [2]
ZD-2138 DMVFCX7 Asthma CA23 Discontinued in Phase 2 [3]
BW A4C DMNUMDG Arthritis FA20 Terminated [4]
KAEMPFEROL DMHEMUB Discovery agent N.A. Investigative [5]
2,4'-Dimethoxy-5,3'-di-(2-propenyl)-biphenyl DMWNJ84 Discovery agent N.A. Investigative [6]
METHYLHONOKIOL DM9YE6K Discovery agent N.A. Investigative [6]
HONOKIOL DMJWT3X Discovery agent N.A. Investigative [6]
PUUPEHEDIONE DMF28IU Discovery agent N.A. Investigative [7]
PUUPEHENONE DMF3BCK Discovery agent N.A. Investigative [7]
Isojaspic acid DMHTBDN Discovery agent N.A. Investigative [7]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
LOX-5 messenger RNA (ALOX5 mRNA) TTSJ6Q4 LOX5_HUMAN Inhibitor [1]

References

1 Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation ... J Med Chem. 1993 Sep 17;36(19):2771-87.
2 New cyclooxygenase-2/5-lipoxygenase inhibitors. 3. 7-tert-butyl-2, 3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflam... J Med Chem. 1998 Aug 27;41(18):3515-29.
3 Synthesis and biological activity of N-aroyl-tetrahydro-gamma-carbolines. Bioorg Med Chem. 2010 Jun 1;18(11):3910-24.
4 Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid. J Med Chem. 2008 Sep 11;51(17):5449-53.
5 Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti. J Nat Prod. 2007 May;70(5):859-62.
6 Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxyge... Bioorg Med Chem. 2009 Jul 1;17(13):4459-65.
7 Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. J Nat Prod. 2009 Oct;72(10):1857-63.