Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4INSG)

• Drug Name: (-)-pinoresinol Drug Info
• Synonyms: Pinoresinol; NSC35444; NSC-35444; bmse010297; AC1Q70QC; (+/-)-PINORESINOL; SCHEMBL122106; AC1L5T18; CHEMBL2252392; CTK2H0032; 4,4'-[(1S,3aR,4S,6aR)-Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis(2-methoxyphenol); HMS3347E17; AKOS025404740; 4,4'-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diylbis(2-methoxyphenol); phenol, 4,4'-(tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis[2-methoxy-; Phenol,4'-(tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis[2-methoxy-, [1S-(1.alpha.,3a.alpha.,4.alpha.,6a.alpha.)]-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 12309636
  ChEBI ID: CHEBI:67245
  TTD Drug ID: DM4INSG

Molecule-Related Drug Atlas

Drug(s) Targeting Arachidonate 15-lipoxygenase (15-LOX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indolizine derivative 1	DM4GZBI	N. A.	N. A.	Patented	[2]
Imidazole derivative 10	DMI7W3K	N. A.	N. A.	Patented	[3]
Indole and benzimidazole derivative 1	DMS0169	N. A.	N. A.	Patented	[3]
Triazole derivative 3	DMZR0TH	N. A.	N. A.	Patented	[3]
Isothiazolone derivative 1	DMHAJCM	N. A.	N. A.	Patented	[3]
PMID26560362-Compound-90	DM9V13U	N. A.	N. A.	Patented	[3]
Imidazole derivative 11	DMTJ0DP	N. A.	N. A.	Patented	[3]
Tri-substituted benzene derivative 1	DMEQ3RD	N. A.	N. A.	Patented	[3]
NSC-661755	DMDJT7U	N. A.	N. A.	Terminated	[4]
KAEMPFEROL	DMHEMUB	Discovery agent	N.A.	Investigative	[1]

Drug(s) Targeting LOX-5 messenger RNA (ALOX5 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TEBUFELONE	DMMUE8P	Pain	MG30-MG3Z	Discontinued in Phase 2	[5]
ZD-2138	DMVFCX7	Asthma	CA23	Discontinued in Phase 2	[6]
BW A4C	DMNUMDG	Arthritis	FA20	Terminated	[7]
KAEMPFEROL	DMHEMUB	Discovery agent	N.A.	Investigative	[1]
2,4'-Dimethoxy-5,3'-di-(2-propenyl)-biphenyl	DMWNJ84	Discovery agent	N.A.	Investigative	[8]
METHYLHONOKIOL	DM9YE6K	Discovery agent	N.A.	Investigative	[8]
HONOKIOL	DMJWT3X	Discovery agent	N.A.	Investigative	[8]
PUUPEHEDIONE	DMF28IU	Discovery agent	N.A.	Investigative	[9]
PUUPEHENONE	DMF3BCK	Discovery agent	N.A.	Investigative	[9]
Isojaspic acid	DMHTBDN	Discovery agent	N.A.	Investigative	[9]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Arachidonate 15-lipoxygenase (15-LOX)	TTN9T81	LOX15_HUMAN	Inhibitor	[1]
LOX-5 messenger RNA (ALOX5 mRNA)	TTSJ6Q4	LOX5_HUMAN	Inhibitor	[1]

References

• [1] Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti. J Nat Prod. 2007 May;70(5):859-62.
• [2] Inhibitors of phospholipase A2 and their therapeutic potential: an update on patents (2012-2016).Expert Opin Ther Pat. 2017 Feb;27(2):217-225.
• [3] 15-Lipoxygenase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):65-88.
• [4] Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorg Med Chem. 2007 Nov 15;15(22):6900-8.
• [5] New cyclooxygenase-2/5-lipoxygenase inhibitors. 3. 7-tert-butyl-2, 3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflam... J Med Chem. 1998 Aug 27;41(18):3515-29.
• [6] Synthesis and biological activity of N-aroyl-tetrahydro-gamma-carbolines. Bioorg Med Chem. 2010 Jun 1;18(11):3910-24.
• [7] Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid. J Med Chem. 2008 Sep 11;51(17):5449-53.
• [8] Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxyge... Bioorg Med Chem. 2009 Jul 1;17(13):4459-65.
• [9] Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. J Nat Prod. 2009 Oct;72(10):1857-63.