Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4JG0B)

Drug Name

DA-3607 Drug Info

Synonyms

Ad-stTRAIL; TRAIL adenoviral gene therapy (cancer), Dong-A

Indication

Disease Entry	ICD 11	Status	REF
Brain cancer	2A00	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting TNF related apoptosis inducing ligand (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ad5-TRAIL	DM2UMGE	Prostate cancer	2C82.0	Phase 1	[3]
ABBV-621	DM90EO3	Haematological malignancy	2B33.Y	Phase 1	[4]
Nimesulide	DMR1NMD	Metastatic colorectal cancer	2B91	Terminated	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
TNF related apoptosis inducing ligand (TNFSF10)	TTA5MS9	TNF10_HUMAN	Binder	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026657)
2	Cancer gene therapy using a novel secretable trimeric TRAIL. Gene Ther. 2006 Feb;13(4):330-8.
3	Enhancement of Ad5-TRAIL cytotoxicity against renal cell carcinoma with histone deacetylase inhibitors. Cancer Gene Ther. 2006 Jun;13(6):628-32.
4	Clinical pipeline report, company report or official report of AbbVie.
5	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.