Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4RK0G)

Drug Name

Divalproex sodium Drug Info

Synonyms

Delepsine; Depakote; Divalproate; Divalproex; Epilex; Epival; Sprinkle; Valcote; Valdisoval; Valparin; Depakote CP; Depakote ER; Depakote Sprinkle; Divalproex sodium [USAN]; Sodium divalproate; Sodium hydrogen divalproate; Valproate semisodique; Valproate semisodique [French]; Valproate semisodium; Valproato semisodico; Valproato semisodico [Spanish]; Valproatum seminatricum; Valproatum seminatricum [Latin]; Abbott 50711; Abbott-50711; Depacon (TN); Depakote (TN); Depakote ER (TN); Divalproex sodium (USP); Epival (TN); Ergenyl Chrono (TN); Valance (TN); Valproate semisodium (INN); Divalproex sodium, Depakote, Epival; Natrium hydrogen bis(2-propylvalerat); Sodium hydrogen bis(2-propylpentanoate); Sodium hydrogen bis(2-propylvalerate); Valproic acid semisodium salt (2:1); Zalkote. (TN); Sodium hydrogen bis(2-propylvalerate), oligomer; Sodium 2-propylpentanoate-2-propylpentanoic acid (1:1); Pentanoic acid, 2-propyl-, sodium salt (2:1); Pentanoic acid, 2-propyl-, sodium salt(2:1); 2-propylpentanoate

Indication

Disease Entry	ICD 11	Status	REF
Seizure disorder	8A6Z	Approved	[1]

Therapeutic Class

Anticonvulsants

Cross-matching ID

PubChem CID: 23663956
ChEBI ID: CHEBI:4667
CAS Number: CAS 76584-70-8
TTD Drug ID: DM4RK0G

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting GABA transaminase (ABAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Alanine	DMZDN4W	Dietary shortage	5B5K	Approved	[2]
Pyridoxal Phosphate	DMO2K0J	Malnutrition	5B50-5B71	Approved	[2]
Pyruvic acid	DM7Q41G	Malnutrition	5B50-5B71	Approved	[2]
Vigabatrin	DMYT0OG	Alcohol dependence	6C40.2	Approved	[3]
CPP-115	DMK9NQI	Tourette syndrome	8A05.00	Phase 2	[4]
K-828-AB	DMJLNZQ	Dementia	6D80-6D86	Phase 2	[5]
CPP -15	DMQCHU3	Infantile spasm	8A62.0	Phase 1	[4]
T83193	DMHO29Y	Discovery agent	N.A.	Patented	[6]
4-hydroxybenzaldehyde	DM471P5	Discovery agent	N.A.	Patented	[7]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
GABA transaminase (ABAT)	TTT2LD9	GABT_HUMAN	Inhibitor	[2]

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References

1	FDA approved drugs (1996) in CenterWatch
2	DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6.
3	Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
4	Clinical pipeline report, company report or official report of Catalyst Pharma.
5	Phase II clinical trial of K-828-AB for treating behavioral and psychological symptoms of dementia. Kowa Co. Ltd.
6	Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives. Bioorg Med Chem Lett. 2006 Feb;16(3):592-5.
7	Inactivation of GABA transaminase by 3-chloro-1-(4-hydroxyphenyl)propan-1-one. Bioorg Med Chem Lett. 2009 Feb 1;19(3):731-4.
8	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.