General Information of Drug (ID: DM4Z9QI)

Drug Name
Olokizumab Drug Info
Indication
Disease Entry ICD 11 Status REF
Rheumatoid arthritis FA20 Phase 3 [1]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2/3 [2]
Cross-matching ID
TTD Drug ID
DM4Z9QI

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug(s) Targeting Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Siltuximab DMGEATB Anemia 3A00-3A9Z Approved [5]
Sirukumab DMK8AQP Cutaneous lupus erythematosus EB5Z Phase 3 [1]
Ziltivekimab DME841B Heart failure BD10-BD13 Phase 3 [6]
RG6179 DMO1VP9 uveitic macular edema 9B78 Phase 3 [7]
PF-04236921 DM826SW Crohn disease DD70 Phase 2 [1]
Clazakizumab DM6ZOUV Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2 Trial [1]
CDP-6038 DM3YB2C Rheumatoid arthritis FA20 Phase 2 [8]
ALD-518 DMPWSBL Psoriatic arthritis FA21 Phase 2 [8]
YSIL6 DM0K8U7 Crohn disease DD70 Phase 2 [9]
Gerilimzumab DMA9UX2 Rheumatoid arthritis FA20 Phase 1 [1]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting HUMAN interleukin 6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Siltuximab DMGEATB Anemia 3A00-3A9Z Approved [10]
Sirukumab DMK8AQP Cutaneous lupus erythematosus EB5Z Phase 3 [11]
Clazakizumab DM6ZOUV Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2 Trial [12]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Interleukin-6 (IL6) TTT1V78 IL6_HUMAN Modulator [3]
HUMAN interleukin 6 (IL6) TTJH4Y5 IL6_HUMAN Inhibitor [4]

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 ClinicalTrials.gov (NCT04380519) Study of the Efficacy and Safety of a Single Administration of Olokizumab and RPH-104 With Standard Therapy in Patients With Severe Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection (COVID-19). U.S. National Institutes of Health.
3 Efficacy and safety of olokizumab in patients with rheumatoid arthritis with an inadequate response to TNF inhibitor therapy: outcomes of a randomised Phase IIb study. Ann Rheum Dis. 2014 September; 73(9): 1607-1615.
4 Discovery and characterization of olokizumab: a humanized antibody targeting interleukin-6 and neutralizing gp130-signaling. MAbs. 2014 May-Jun;6(3):774-82.
5 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
6 IL-6 inhibition with ziltivekimab in patients at high atherosclerotic risk (RESCUE): a double-blind, randomised, placebo-controlled, phase 2 trial. Lancet. 2021 May 29;397(10289):2060-2069.
7 Clinical pipeline report, company report or official report of Roche
8 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
9 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020380)
10 Siltuximab. In: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. 2018 Dec 3.
11 Sirukumab: A Potential Treatment for Mood Disorders Adv Ther. 2017 Jan;34(1):78-90.
12 Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS) J Autoimmun. 2020 Apr 10:102452.