Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM52IQF)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting Oxysterols receptor LXR-alpha (NR1H3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US9073931, E2	DMK9FJG	N. A.	N. A.	Patented	[2]
BDBM50177019	DMEL28G	N. A.	N. A.	Patented	[1]
US9006244, E2b	DMP0TBO	N. A.	N. A.	Patented	[3]
US9073931, E1	DM2Z43I	N. A.	N. A.	Patented	[2]
US9006244, E1	DMBF1C0	N. A.	N. A.	Patented	[3]
US9006244, E2a	DMPDF9B	N. A.	N. A.	Patented	[3]
67S	DMJL1MB	N. A.	N. A.	Patented	[1]
US9073931, E3	DMCYM8P	N. A.	N. A.	Patented	[2]
desmosterol	DMV8SUM	Discovery agent	N.A.	Investigative	[4]
L-783483	DM6OTGE	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Oxysterols receptor LXR-alpha (NR1H3)	TTECBXN	NR1H3_HUMAN	Inhibitor	[1]

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References

1	Piperazine derivatives as liver X receptor modulators. US10144715.
2	Liver X receptor modulators. US9073931.
3	Liver X receptor modulators. US9006244.
4	Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. J Biol Chem. 2006 Sep 22;281(38):27816-26.
5	A novel liver X receptor agonist establishes species differences in the regulation of cholesterol 7alpha-hydroxylase (CYP7a). Endocrinology. 2002 Jul;143(7):2548-58.