General Information of Drug (ID: DM53J6B)

Drug Name
PDR001 Drug Info
Indication
Disease Entry ICD 11 Status REF
Melanoma 2C30 Phase 3 [1]
Esophageal squamous cell carcinoma 2E60.1 Phase 2 [2]
Neuroendocrine cancer 2B72.1 Phase 2 [3]
Lymphoma 2A80-2A86 Phase 1 [3]
Solid tumour/cancer 2A00-2F9Z Phase 1 [3]
Cross-matching ID
TTD Drug ID
DM53J6B

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nivolumab DMAB9QE Melanoma 2C30 Approved [5]
Tislelizumab DMGVUO5 Hodgkin lymphoma 2B30 Approved [6]
MK-3475 DMBYNW0 Melanoma 2C30 Approved [5]
Pembrolizumab DMFQEA6 Melanoma 2C30 Approved [7]
Cemiplimab DMKMJHE Cutaneous squamous cell carcinoma 2C30 Approved [8]
Retifanlimab DMRKTCP Neuroendocrine cancer 2B72.1 Approved [3]
Sintilimab DMGWR0C Hodgkin lymphoma 2B30 Approved [9]
Dostarlimab DM78NWP Endometrial cancer 2C76 Approved [10]
Toripalimab DMSGA6Z Demodex blepharitis 1G07 Approved in China [11]
BGB-A317 DM7NJYC Hepatocellular carcinoma 2C12.02 Phase 3 [3]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Programmed cell death protein 1 (PD-1) TTNBFWK PDCD1_HUMAN Antagonist [4]

References

1 ClinicalTrials.gov (NCT02967692) A Study of the Anti-PD1 Antibody PDR001, in Combination With Dabrafenib and Trametinib in Advanced Melanoma (COMBI-i). U.S. National Institutes of Health.
2 ClinicalTrials.gov (NCT03785496) Study to Evaluate Efficacy of PDR001 in Patients With Squamous Cell Carcinoma of the Esophagus. U.S. National Institutes of Health.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
6 Tislelizumab: an investigational anti-PD-1 antibody for the treatment of advanced non-small cell lung cancer (NSCLC). Expert Opin Investig Drugs. 2020 Dec;29(12):1355-1364.
7 Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730.
8 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
9 Sintilimab: First Global Approval. Drugs. 2019 Feb;79(3):341-346.
10 Dostarlimab in the treatment of recurrent or primary advanced endometrial cancer. Future Oncol. 2021 Mar;17(8):877-892.
11 Toripalimab: the First Domestic Anti-Tumor PD-1 Antibody in China. Front Immunol. 2022 Jan 12;12:730666.