Details of the Drug

General Information of Drug (ID: DM53J6B)

Drug Name
PDR001
Indication
Disease Entry ICD 11 Status REF
Melanoma 2C30 Phase 3 [1]
Esophageal squamous cell carcinoma 2E60.1 Phase 2 [2]
Neuroendocrine cancer 2B72.1 Phase 2 [3]
Lymphoma 2A80-2A86 Phase 1 [3]
Solid tumour/cancer 2A00-2F9Z Phase 1 [3]
Drug Type
Antibody
Cross-matching ID
TTD ID
D05BAJ
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Programmed cell death protein 1 (PD-1) TTNBFWK PDCD1_HUMAN Antagonist [4]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

ICD Disease Classification 02 Neoplasm
Disease Class ICD-11: 2C82 Prostate cancer
The Studied Tissue Skin
The Studied Disease Melanoma [ICD-11:2C82]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Programmed cell death protein 1 (PD-1) DTT PDCD1 7.26E-01 -0.01 -0.03
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 ClinicalTrials.gov (NCT02967692) A Study of the Anti-PD1 Antibody PDR001, in Combination With Dabrafenib and Trametinib in Advanced Melanoma (COMBI-i). U.S. National Institutes of Health.
2 ClinicalTrials.gov (NCT03785496) Study to Evaluate Efficacy of PDR001 in Patients With Squamous Cell Carcinoma of the Esophagus. U.S. National Institutes of Health.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)