Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5IUN8)

Drug Name

12B9m Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Anaemia	3A90	Preclinical	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Hepcidin (HAMP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NOX-H94	DM5HPZU	Anemia	3A00-3A9Z	Phase 2	[3]
PTG-300	DMOYS8A	Hemochromatosis	5C64.1Y	Phase 2	[4]
LJPC-401	DMVM13R	Beta thalassemia	3A50.2	Phase 2	[5]
Hepcidin mab	DMBFYSR	Anemia	3A00-3A9Z	Phase 1	[6]
LY2787106	DM9NYHT	Anemia	3A00-3A9Z	Phase 1	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	Targeting iron metabolism in drug discovery and delivery. Nat Rev Drug Discov. 2017 Jun;16(6):400-423.
2	Pharmacokinetics of anti-hepcidin monoclonal antibody Ab 12B9m and hepcidin in cynomolgus monkeys. AAPS J. 2010 Dec;12(4):646-57.
3	The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys. Blood. 2013 Mar 21;121(12):2311-5.
4	Clinical pipeline report, company report or official report of Protagonist Therapeutics.
5	ClinicalTrials.gov (NCT03395704) A Study of LJPC-401 for the Treatment of Iron Overload in Adult Patients With Hereditary Hemochromatosis. U.S. National Institutes of Health.
6	The pathophysiology and pharmacology of hepcidin. Trends Pharmacol Sci. 2014 March; 35(3): 155-161.
7	A first-in-human phase 1 study of a hepcidin monoclonal antibody, LY2787106, in cancer-associated anemia. J Hematol Oncol. 2017 Mar 21;10(1):73.