Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5OHYE)

Drug Name

Bacitracin Drug Info

Synonyms

Altracin; Baciguent; Baciquent; Citracin; Fortracin; Bacitracin A; Bacitracin A1; Bacitracin A2a; Neosporin (TN); Solu-Tracin 50; Partyl-, (10.4)-lactam; L-Asparagine, N-[[(4R)-2-[(1S,2S)-1-amino-2-methylbutyl]-4,5-dihydro-4-thiazolyl]carbonyl]-L-leucyl-D-.alpha.-glutamyl-L-isoleucyl-L-lysyl-D-ornithyl-L-isoleucyl-D-phenylalanyl-L-histidyl-D-.alpha.-as; 11702_FLUKA; 11702_SIGMA

Indication

Disease Entry	ICD 11	Status	REF
Blepharoconjunctivitis		Approved	[1]
Corneal abrasion	NA06.4	Approved	[1]
Keratitis		Approved	[1]
Skin infection	1F28-1G0Z	Approved	[2]

Therapeutic Class

Antibiotics

Cross-matching ID

PubChem CID: 10909430
ChEBI ID: CHEBI:35862
CAS Number: CAS 1405-87-4
TTD Drug ID: DM5OHYE

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Insulin-degrading enzyme (IDE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PRO-001	DM5ZTE4	Retinitis pigmentosa	9B70	Phase 2	[5]
GNF-PF-4478	DMCDU8K	Discovery agent	N.A.	Investigative	[6]
quinoline 2	DM1QIPZ	Discovery agent	N.A.	Investigative	[7]
NTE-2	DM4DB0W	Discovery agent	N.A.	Investigative	[7]
NTE-1	DMFIE0U	Discovery agent	N.A.	Investigative	[7]
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Drug(s) Metabolized By Endoglucanase Y (EGY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[4]
Colistin	DMMD9QE	Pseudomonas infection	1B92	Approved	[4]
Kanamycin	DM2DMPO	Bacteremia	1A73	Approved	[4]
Streptomycin	DME1LQN	Bacterial infection	1A00-1C4Z	Approved	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Insulin-degrading enzyme (IDE)	TT2EDHU	IDE_HUMAN	Inhibitor	[3]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Endoglucanase A (EGA)	DEK9LVM	A0A660DUI5_9LACO	Substrate	[4]
Endoglucanase Y (EGY)	DE2M583	A0A256VAC0_LACRE	Substrate	[4]

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References

1	Bacitracin FDA Label
2	Has nature already identified all useful antibacterial targets Curr Opin Microbiol. 2008 Oct;11(5):387-92.
3	Brain insulin impairs amyloid-beta(1-40) clearance from the brain. J Neurosci. 2004 Oct 27;24(43):9632-7.
4	Expression of Clostridium thermocellum endoglucanase gene in Lactobacillus gasseri and Lactobacillus johnsonii and characterization of the genetically modified probiotic lactobacilli. Curr Microbiol. 2000 Apr;40(4):257-63.
5	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2371).
6	In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6.
7	Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo. J Biol Chem. 2015 Aug 14;290(33):20044-59.