General Information of Drug (ID: DM5T2FR)

Drug Name
PMID18800762C14 Drug Info
Synonyms bisphosphonate, 14; GTPL3194; BDBM25258
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
25023861
TTD Drug ID
DM5T2FR

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [2]
Minodronate DM50PMY Osteoporosis FB83.0 Approved [3]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [2]
Alendronate DMY2KX9 Bone Paget disease Approved [2]
Pamidronate DMB4AVP Bone Paget disease Approved [4]
Incadronate DM3DSVJ Hypercalcaemia 5B91.0 Approved [5]
Risedronate DM5FLTY Bone Paget disease Approved [6]
NERIDRONIC ACID DMMPG5V Bone disease FC0Z Approved [7]
Zarnestra DMF30HL Acute myeloid leukaemia 2A60 Phase 3 [8]
GERANYLGERANYL DIPHOSPHATE DMJZ0AM Discovery agent N.A. Investigative [9]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Geranyltranstransferase (FDPS) TTIKWV4 FPPS_HUMAN Inhibitor [1]

References

1 Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. J Med Chem. 2008 Sep 25;51(18):5594-607.
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
3 Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid. J Med Chem. 2010 May 13;53(9):3454-64.
4 Detection of nonsterol isoprenoids by HPLC-MS/MS. Anal Biochem. 2008 Dec 1;383(1):18-24.
5 Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J Pharmacol Exp Ther. 2001 Feb;296(2):235-42.
6 Activity of bisphosphonates against Trypanosoma brucei rhodesiense. J Med Chem. 2002 Jul 4;45(14):2904-14.
7 Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of hu... J Med Chem. 2008 Apr 10;51(7):2187-95.
8 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
9 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.