Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5T2FR)

• Drug Name: PMID18800762C14 Drug Info
• Synonyms: bisphosphonate, 14; GTPL3194; BDBM25258

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 25023861
  TTD Drug ID: DM5T2FR

Molecule-Related Drug Atlas

Drug(s) Targeting Geranyltranstransferase (FDPS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[2]
Minodronate	DM50PMY	Osteoporosis	FB83.0	Approved	[3]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[2]
Alendronate	DMY2KX9	Bone Paget disease		Approved	[2]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[4]
Incadronate	DM3DSVJ	Hypercalcaemia	5B91.0	Approved	[5]
Risedronate	DM5FLTY	Bone Paget disease		Approved	[6]
NERIDRONIC ACID	DMMPG5V	Bone disease	FC0Z	Approved	[7]
Zarnestra	DMF30HL	Acute myeloid leukaemia	2A60	Phase 3	[8]
GERANYLGERANYL DIPHOSPHATE	DMJZ0AM	Discovery agent	N.A.	Investigative	[9]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Geranyltranstransferase (FDPS)	TTIKWV4	FPPS_HUMAN	Inhibitor	[1]

References

• [1] Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. J Med Chem. 2008 Sep 25;51(18):5594-607.
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [3] Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid. J Med Chem. 2010 May 13;53(9):3454-64.
• [4] Detection of nonsterol isoprenoids by HPLC-MS/MS. Anal Biochem. 2008 Dec 1;383(1):18-24.
• [5] Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J Pharmacol Exp Ther. 2001 Feb;296(2):235-42.
• [6] Activity of bisphosphonates against Trypanosoma brucei rhodesiense. J Med Chem. 2002 Jul 4;45(14):2904-14.
• [7] Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of hu... J Med Chem. 2008 Apr 10;51(7):2187-95.
• [8] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [9] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.