General Information of Drug (ID: DM5TDFQ)

Drug Name
[3H]nitrobenzylmercaptopurine ribonucleoside Drug Info
Synonyms [3H]NBTI; [3H]-NBTI; (2S,3R,4S,5R)-2-(6-hydroxy-9H-purin-9-yl)-5-(hydroxymethyl)-2-{[(2-nitrophenyl)methyl]sulfanyl}oxolane-3,4-diol; [3H]NBMPR; SCHEMBL290700; GTPL4511
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
135796589
TTD Drug ID
DM5TDFQ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
LIDOFLAZINE DMV23GL Angina pectoris BA40 Approved [3]
N6-CYCLOPENTYLADENOSINE DMD6AJO Discovery agent N.A. Investigative [4]
Dilazep DMOD5Y0 Discovery agent N.A. Investigative [5]
S6-nitrobenzyl mercaptopurine riboside DMIKJNL Discovery agent N.A. Investigative [6]
KF24345 DMK6SMW Discovery agent N.A. Investigative [7]
NBTGR DMVF420 Discovery agent N.A. Investigative [2]
9-Benzyl-6-(4-nitro-benzylsulfanyl)-9H-purine DMNY5P1 Discovery agent N.A. Investigative [8]
Nitrobenzylthioinosine DM7F3RY Discovery agent N.A. Investigative [9]
6-(4-Nitro-benzylsulfanyl)-9-phenethyl-9H-purine DMPL5XV Discovery agent N.A. Investigative [8]
⏷ Show the Full List of 9 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Solute carrier family 29 member 1 (SLC29A1) TTLXAKE S29A1_HUMAN Modulator [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4511).
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1117).
3 Synthesis, flow cytometric evaluation, and identification of highly potent dipyridamole analogues as equilibrative nucleoside transporter 1 inhibit... J Med Chem. 2007 Aug 9;50(16):3906-20.
4 Inhibition of nucleoside transport proteins by C8-alkylamine-substituted purines. J Med Chem. 2005 Jan 13;48(1):321-9.
5 Residues Met89 and Ser160 in the human equilibrative nucleoside transporter 1 affect its affinity for adenosine, guanosine, S6-(4-nitrobenzyl)-merc... Mol Pharmacol. 2005 Mar;67(3):837-44.
6 Synthesis and biological evaluation of phloridzin analogs as human concentrative nucleoside transporter 3 (hCNT3) inhibitors. Bioorg Med Chem Lett. 2009 Feb 1;19(3):917-21.
7 Interaction of the novel adenosine uptake inhibitor 3-[1-(6,7-diethoxy-2-morpholinoquinazolin-4-yl)piperidin-4-yl]-1,6-dimethyl-2,4(1H,3H)-quinazol... J Pharmacol Exp Ther. 2004 Mar;308(3):1083-93.
8 Inhibition of nucleoside transport by new analogues of 4-nitrobenzylthioinosine: replacement of the ribose moiety by substituted benzyl groups. J Med Chem. 2004 Oct 21;47(22):5441-50.
9 The role of human nucleoside transporters in uptake of 3'-deoxy-3'-fluorothymidine. Mol Pharmacol. 2008 Nov;74(5):1372-80.