Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5WETL)

• Drug Name: (S)-FTY720P Drug Info
• Synonyms: CHEMBL1213480
• Cross-matching ID:
  PubChem CID: 11452022
  CAS Number: CAS 402616-26-6
  TTD Drug ID: DM5WETL

Molecule-Related Drug Atlas

Drug(s) Targeting Sphingosine-1-phosphate receptor 1 (S1PR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Siponimod	DM2R86O	Multiple sclerosis	8A40	Approved	[2]
Fingolimod	DM5JVAN	Multiple sclerosis	8A40	Approved	[3]
Ozanimod	DMT6AM2	Multiple sclerosis	8A40	Approved	[4]
Etrasimod	DMT0A3Y	Ulcerative colitis	DD71	Approved	[5]
Ponesimod	DMEAOYJ	Multiple sclerosis	8A40	Approved	[6]
MT-1303	DMSE9TH	Crohn disease	DD70	Phase 2	[7]
ONO-4641	DMLUM3Y	Rheumatoid arthritis	FA20	Phase 2	[8]
KRP-203	DMOW9X2	Cutaneous lupus erythematosus	EB5Z	Phase 2	[8]
VTX-002	DMZ8Z5A	Ulcerative colitis	DD71	Phase 2	[9]
CBP-307	DM3TH6Y	Ulcerative colitis	DD71	Phase 2	[10]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Sphingosine-1-phosphate receptor 1 (S1PR1)	TT9JZCK	S1PR1_HUMAN	Inhibitor	[1]

References

• [1] Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors. Nat Chem Biol. 2009 Jun;5(6):428-34.
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
• [3] Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
• [4] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
• [5] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [6] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2021
• [7] Sphingosine 1-Phosphate Receptor Modulators in Multiple Sclerosis. CNS Drugs. 2015 Jul;29(7):565-75.
• [8] Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond. Nat Rev Drug Discov. 2013 Sep;12(9):688-702.
• [9] Clinical pipeline report, company report or official report of Ventyx Biosciences
• [10] Clinical pipeline report, company report or official report of Connect Biopharma