Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5X849)

• Drug Name: MEDI4736 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 3	[1]

• Cross-matching ID: TTD Drug ID: DM5X849

Molecule-Related Drug Atlas

Drug(s) Targeting Programmed cell death 1 ligand 1 (PD-L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Avelumab	DMSZLJR	Merkel cell carcinoma	2C34	Approved	[3]
Durvalumab	DM4PVDY	Urothelial carcinoma	2C92.0	Approved	[4]
RG-7446	DM69XMQ	Urothelial carcinoma	2C92.0	Approved	[5]
Bavencio	DMU9C8F	Merkel cell carcinoma	2C34	Approved	[6]
Atezolizumab	DMMF8U0	Non-small-cell lung cancer	2C25	Approved	[7]
Sugemalimab	DMH5YQ3	Non-small-cell lung cancer	2C25	Approved in China	[8]
KN046	DMSDBPG	Non-small-cell lung cancer	2C25.Y	Phase 3	[9]
MPDL-3280A	DM9K3LM	Melanoma	2C30	Phase 3	[10]
CS1001	DMSY0NE	Non-small-cell lung cancer	2C25	Phase 3	[11]
A167	DME00MM	Nasopharyngeal carcinoma	2B6B	Phase 3	[12]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Programmed cell death 1 ligand 1 (PD-L1)	TT8ZLTI	PD1L1_HUMAN	Modulator	[2]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7985).
• [2] National Cancer Institute Drug Dictionary (drug id 740856).
• [3] Antibody-Dependent Cellular Cytotoxicity Activity of a Novel Anti-PD-L1 Antibody Avelumab (MSB0010718C) on Human Tumor Cells. Cancer Immunol Res. 2015 Oct;3(10):1148-57.
• [4] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [5] PD-1 as a potential target in cancer therapy. Cancer Med. 2013 October; 2(5): 662-673.
• [6] ClinicalTrials.gov (NCT03403777) Avelumab in Refractory Testicular Germ Cell Cancer.. U.S. National Institutes of Health.
• [7] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
• [8] Sugemalimab: First Approval. Drugs. 2022 Apr;82(5):593-599.
• [9] Clinical pipeline report, company report or official report of Alphamab Oncology.
• [10] Targeted immunotherapy for non-small cell lung cancer. World J Clin Oncol. 2014 May 10; 5(2): 39-47.
• [11] GEMSTONE-301: a phase III clinical trial of CS1001 as consolidation therapy in patients with locally advanced/unresectable (stage III) non-small cell lung cancer (NSCLC) who did not have disease progression after prior concurrent/sequential chemoradiotherapy. Transl Lung Cancer Res. 2020 Oct;9(5):2008-2015.
• [12] Clinical pipeline report, company report or official report of Klus Pharma