Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5XGM9)

• Drug Name: CS-1003 Drug Info
• Synonyms: Nofazinlimab

Indication

Disease Entry	ICD 11	Status	REF
Hepatocellular carcinoma	2C12.02	Phase 3	[1]

• Cross-matching ID: TTD Drug ID: DM5XGM9

Molecule-Related Drug Atlas

Drug(s) Targeting Programmed cell death protein 1 (PD-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nivolumab	DMAB9QE	Melanoma	2C30	Approved	[3]
Tislelizumab	DMGVUO5	Hodgkin lymphoma	2B30	Approved	[4]
MK-3475	DMBYNW0	Melanoma	2C30	Approved	[3]
Pembrolizumab	DMFQEA6	Melanoma	2C30	Approved	[5]
Cemiplimab	DMKMJHE	Cutaneous squamous cell carcinoma	2C30	Approved	[6]
Retifanlimab	DMRKTCP	Neuroendocrine cancer	2B72.1	Approved	[7]
Sintilimab	DMGWR0C	Hodgkin lymphoma	2B30	Approved	[8]
Dostarlimab	DM78NWP	Endometrial cancer	2C76	Approved	[9]
Toripalimab	DMSGA6Z	Demodex blepharitis	1G07	Approved in China	[10]
PDR001	DM53J6B	Melanoma	2C30	Phase 3	[11]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Programmed cell death protein 1 (PD-1)	TTNBFWK	PDCD1_HUMAN	Not Available	[2]

References

• [1] ClinicalTrials.gov (NCT04194775) A Multi-Center, Double-Blind, Randomized, Phase III Study to Investigate the Efficacy and Safety of Nofazinlimab (CS1003) in Combination With Lenvatinib Compared to Placebo in Combination With Lenvatinib as First-Line Therapy in Subjects With Advanced Hepatocellular Carcinoma (HCC). U.S.National Institutes of Health.
• [2] CS1003, a novel human and mouse cross-reactive PD-1 monoclonal antibody for cancer therapy. Acta Pharmacol Sin. 2021 Jan;42(1):142-148.
• [3] 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
• [4] Tislelizumab: an investigational anti-PD-1 antibody for the treatment of advanced non-small cell lung cancer (NSCLC). Expert Opin Investig Drugs. 2020 Dec;29(12):1355-1364.
• [5] Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730.
• [6] 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
• [7] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [8] Sintilimab: First Global Approval. Drugs. 2019 Feb;79(3):341-346.
• [9] Dostarlimab in the treatment of recurrent or primary advanced endometrial cancer. Future Oncol. 2021 Mar;17(8):877-892.
• [10] Toripalimab: the First Domestic Anti-Tumor PD-1 Antibody in China. Front Immunol. 2022 Jan 12;12:730666.
• [11] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)