General Information of Drug (ID: DM65SQK)

Drug Name
GRANULATIMIDE Drug Info
Synonyms
GRANULATIMIDE; CHEMBL240747; 219828-99-6; SCHEMBL4238896; CTK1A7209; DTXSID90415922; BDBM50216165; 1,11-dihydro-1,3,5,11-tetraaza-benzo[a]trindene-4,6-dione; 3,11-Dihydro-1,3,5,11-tetraaza-benzo[a]trindene-4,6-dione; 1H-Imidazo[4,5-a]pyrrolo[3,4-c]carbazole-4,6(5H,11H)-dione
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5324595
CAS Number
CAS 219828-99-6
TTD Drug ID
DM65SQK

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Drug(s) Targeting Checkpoint kinase-1 (CHK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
LY2603618 DMCXRZF Pancreatic cancer 2C10 Phase 2 [2]
UCN-01 DMUNJZB Non-small-cell lung cancer 2C25.Y Phase 2 [3]
SCH-900776 DM67EMK Solid tumour/cancer 2A00-2F9Z Phase 2 [4]
LY2606368 DM4XMF7 Ovarian cancer 2C73 Phase 2 [5]
LY2880070 DMADEHZ Solid tumour/cancer 2A00-2F9Z Phase 1/2 [6]
RG7741 DMK6P9J Lymphoma 2A80-2A86 Phase 1 [7]
GDC-0425 DMDZ26X Lymphoma 2A80-2A86 Phase 1 [8]
AZD7762 DM1FW0C Solid tumour/cancer 2A00-2F9Z Phase 1 [9]
MK-8776 DMAS1RB Hodgkin lymphoma 2B30 Phase 1 [10]
Diamidothiazole derivative 1 DM02V5Q N. A. N. A. Patented [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Checkpoint kinase-1 (CHK1) TTTU902 CHK1_HUMAN Inhibitor [1]

References

1 Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of pyrrolo[3,4-a]carbazole-1,3-diones, pyrrolo[3,4-c]carbazole-1,3... Eur J Med Chem. 2008 Feb;43(2):282-92.
2 Characterization and preclinical development of LY2603618: a selective and potent Chk1 inhibitor. Invest New Drugs. 2014 Apr;32(2):213-26.
3 Characterization of an inhibitory dynamic pharmacophore for the ERCC1-XPA interaction using a combined molecular dynamics and virtual screening app... J Mol Graph Model. 2009 Sep;28(2):113-30.
4 Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening. Mol Cancer Ther. 2011 Apr;10(4):591-602.
5 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6 A phase Ib study of oral Chk1 inhibitor LY2880070 in combination with gemcitabine in patients with advanced or metastatic cancer. Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020) 3581-3581.
7 National Cancer Institute Drug Dictionary (drug id 730054).
8 Quantitative assessment of BCL-2:BIM complexes as a pharmacodynamic marker for venetoclax (ABT-199).
9 Clinical pipeline report, company report or official report of AstraZeneca (2009).
10 Chk1 Inhibitor MK-8776 Restores the Sensitivity of Chemotherapeutics in P-glycoprotein Overexpressing Cancer Cells. Int J Mol Sci. 2019 Aug 22;20(17):4095.
11 Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70.