Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6HI8W)

Drug Name

trans-3-ACPBPA Drug Info

Synonyms

trans-3-ACPBPA; SCHEMBL4586130; GTPL4099; [(1R,3R)-3-aminocyclopentyl](butyl)phosphinic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting GABA(A) receptor rho3 (GABRR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TBPS	DMFC3XP	Discovery agent	N.A.	Investigative	[4]
isonipecotic acid	DMO1ZHE	Discovery agent	N.A.	Investigative	[4]
piperidine-4-sulphonic acid	DMMIZWE	Discovery agent	N.A.	Investigative	[4]
cis-3-ACPBPA	DMQ0EA7	Discovery agent	N.A.	Investigative	[4]
5-Me-IAA	DMFZN7J	Discovery agent	N.A.	Investigative	[4]
aza-THIP	DML70NC	Discovery agent	N.A.	Investigative	[4]
TPMPA	DMBF6KS	Discovery agent	N.A.	Investigative	[4]
(+/-)-cis-2-CAMP	DMY3J0B	Discovery agent	N.A.	Investigative	[4]
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Drug(s) Targeting GABA(A) receptor rho2 (GABRR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TBPS	DMFC3XP	Discovery agent	N.A.	Investigative	[3]
isonipecotic acid	DMO1ZHE	Discovery agent	N.A.	Investigative	[3]
piperidine-4-sulphonic acid	DMMIZWE	Discovery agent	N.A.	Investigative	[3]
cis-3-ACPBPA	DMQ0EA7	Discovery agent	N.A.	Investigative	[3]
5-Me-IAA	DMFZN7J	Discovery agent	N.A.	Investigative	[3]
aza-THIP	DML70NC	Discovery agent	N.A.	Investigative	[3]
TPMPA	DMBF6KS	Discovery agent	N.A.	Investigative	[3]
(+/-)-cis-2-CAMP	DMY3J0B	Discovery agent	N.A.	Investigative	[3]
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Drug(s) Targeting GABA(A) receptor rho1 (GABRR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TBPS	DMFC3XP	Discovery agent	N.A.	Investigative	[2]
isonipecotic acid	DMO1ZHE	Discovery agent	N.A.	Investigative	[2]
piperidine-4-sulphonic acid	DMMIZWE	Discovery agent	N.A.	Investigative	[2]
cis-3-ACPBPA	DMQ0EA7	Discovery agent	N.A.	Investigative	[2]
5-Me-IAA	DMFZN7J	Discovery agent	N.A.	Investigative	[2]
aza-THIP	DML70NC	Discovery agent	N.A.	Investigative	[2]
TPMPA	DMBF6KS	Discovery agent	N.A.	Investigative	[2]
(+/-)-cis-2-CAMP	DMY3J0B	Discovery agent	N.A.	Investigative	[2]
CACA	DMPKFYZ	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
GABA(A) receptor rho1 (GABRR1)	TT6XFEU	GBRR1_HUMAN	Antagonist	[2]
GABA(A) receptor rho2 (GABRR2)	TTQMXLS	GBRR2_HUMAN	Antagonist	[3]
GABA(A) receptor rho3 (GABRR3)	TT4N6D8	GBRR3_HUMAN	Antagonist	[4]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4099).
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 420).
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 421).
4	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 422).
5	Characterization of bicuculline/baclofen-insensitive (rho-like) gamma-aminobutyric acid receptors expressed in Xenopus oocytes. II. Pharmacology of gamma-aminobutyric acidA and gamma-aminobutyric acidB receptor agonists and antagonists. Mol Pharmacol. 1993 Apr;43(4):609-25.