Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6J085)

Drug Name

M6223 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting V-set and immunoglobulin domain-containing protein 9 (TIGIT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ociperlimab	DMEDSVJ	Non-small-cell lung cancer	2C25.Y	Phase 3	[2]
AB154	DMUES7Y	Non-small-cell lung cancer	2C25	Phase 3	[3]
GSK4428859	DMIOIU8	Aggressive cancer	2A00-2F9Z	Phase 2	[4]
Rilvegostomig	DMDWCM2	Non-small-cell lung cancer	2C25	Phase 1/2	[5]
ASP8374	DMA71OL	Solid tumour/cancer	2A00-2F9Z	Phase 1	[6]
SEA-TGT	DM7GUH3	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]
COM902	DMR6T8L	Solid tumour/cancer	2A00-2F9Z	Phase 1	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
V-set and immunoglobulin domain-containing protein 9 (TIGIT)	TTWNL74	TIGIT_HUMAN	Inhibitor	[1]

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References

1	ClinicalTrials.gov (NCT04457778) First in Human Study of M6223. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of BeiGene.
3	Clinical pipeline report, company report or official report of Arcus Biosciences.
4	Clinical pipeline report, company report or official report of GlaxoSmithKline
5	ClinicalTrials.gov (NCT04995523) Phase I/II, Open-label, Dose Escalation and Dose Expansion Study to Evaluate Safety, Pharmacokinetics, Pharmacodynamics and Efficacy of AZD2936 Anti-TIGIT/Anti-PD-1 Bispecific Antibody in Participants With Advanced or Metastatic NSCLC. U.S.National Institutes of Health.
6	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
7	Clinical pipeline report, company report or official report of Seagen.
8	COM902, a novel therapeutic antibody targeting TIGIT augments anti-tumor T cell function in combination with PVRIG or PD-1 pathway blockade. Cancer Immunol Immunother. 2021 Apr 26.