Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6L5TR)

Drug Name
EGEN-001 Drug Info
Indication
Disease Entry ICD 11 Status REF
Fallopian tube cancer 2C74 Phase 2 [1]
Ovarian cancer 2C73 Phase 2 [1]
Peritoneal cancer 2C51.Z Phase 2 [1]
Cross-matching ID
TTD Drug ID
DM6L5TR

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Interleukin-12 beta (IL12B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isoproterenol DMK7MEY Atrioventricular block Approved [3]
ABT-874 DMYHSO2 Plaque psoriasis EA90.0 Phase 3 [4]
SFV IL-12 gene therapy DMVIWNK Breast cancer 2C60-2C65 Phase 2 [5]
Ad-IL-12 DNA therapeutic DMB19IO Melanoma 2C30 Phase 1/2 [6]
NHS-IL 12 DMU6CQ7 Solid tumour/cancer 2A00-2F9Z Phase 1 [7]
PF-07261271 DM0K4WQ Inflammatory bowel disease DD72 Phase 1 [8]
⏷ Show the Full List of 6 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Interleukin-12 beta (IL12B) TTGW72V IL12B_HUMAN Modulator [2]

References

1 ClinicalTrials.gov (NCT01118052) EGEN-001 in Treating Patients With Persistent or Recurrent Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer. U.S. National Institutes ofHealth.
2 National Cancer Institute Drug Dictionary (drug id 454593).
3 A phase 1 study of AS1409, a novel antibody-cytokine fusion protein, in patients with malignant melanoma or renal cell carcinoma. Clin Cancer Res. 2011 Apr 1;17(7):1998-2005.
4 Briakinumab for the treatment of plaque psoriasis.BioDrugs.2012 Feb 1;26(1):9-20.
5 Clinical pipeline report, company report or official report of Trademarkia.
6 National Cancer Institute Drug Dictionary (drug id 710508).
7 The immunocytokine NHS-IL12 as a potential cancer therapeutic. Oncotarget. 2014 Apr 15;5(7):1869-84.
8 Clinical pipeline report, company report or official report of Pfizer