Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6LDI4)

Drug Name
BMS-986158 Drug Info
Synonyms
KGERZPVQIRYWRK-GDLZYMKVSA-N; 1800340-40-2; UNII-X8BW0MQ5PI; X8BW0MQ5PI; SCHEMBL16861831; EX-A2678; CS-7497; HY-101567; (S)-2-(3-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-5-(phenyl(tetrahydro-2H-pyran-4-yl)methyl)-5H-pyrido[3,2-b]indol-7-yl)propan-2-ol
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1/2 [1]
Cross-matching ID
PubChem CID
118196485
CAS Number
CAS 1800340-40-2
TTD Drug ID
DM6LDI4

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Bromodomain and extraterminal domain protein (BET)
Drug Name Drug ID Indication ICD 11 Highest Status REF
CPI-0610 DMPXOYJ Myelofibrosis 2A20.2 Phase 3 [2]
ZEN-3694 DM6VQTF Prostate cancer 2C82.0 Phase 2 [3]
OTX-015 DMI8RG1 Acute myeloid leukaemia 2A60 Phase 1/2 [2]
INCB054329 DM7TZL0 Refractory hematologic malignancy 2A85.5 Phase 1/2 [4]
INCB057643 DMG65CV Solid tumour/cancer 2A00-2F9Z Phase 1/2 [5]
ODM-207 DMOKVJD Solid tumour/cancer 2A00-2F9Z Phase 1/2 [6]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [7]
GSK525762 DMPAWBN Haematological malignancy 2B33.Y Phase 1 [2]
PLX51107 DMXLHVW Haematological malignancy 2B33.Y Phase 1 [2]
BI 894999 DM7W5N2 Solid tumour/cancer 2A00-2F9Z Phase 1 [2]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bromodomain and extraterminal domain protein (BET) TTE4BSY NOUNIPROTAC Inhibitor [2]

References

1 ClinicalTrials.gov (NCT02419417) Study of BMS-986158 in Subjects With Select Advanced Cancers (BET). U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Clinical pipeline report, company report or official report of Zenith Epigenetics.
4 The Novel Bromodomain and Extraterminal Domain Inhibitor INCB054329 Induces Vulnerabilities in Myeloma Cells That Inform Rational Combination Strategies. Clin Cancer Res. 2019 Jan 1;25(1):300-311.
5 Development of 2 Bromodomain and Extraterminal Inhibitors With Distinct Pharmacokinetic and Pharmacodynamic Profiles for the Treatment of Advanced Malignancies. Clin Cancer Res. 2020 Mar 15;26(6):1247-1257.
6 First-in-human Phase 1 open label study of the BET inhibitor ODM-207 in patients with selected solid tumours. Br J Cancer. 2020 Dec;123(12):1730-1736.
7 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)