Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6P8HU)

• Drug Name: Dutasteride + tamsulosin Drug Info
• Synonyms: Jalyn; Dutasteride / tamsulosin; Tamsulosin / Dutasteride; Dutasteride mixture with tamsulosin

Indication

Disease Entry	ICD 11	Status	REF
Benign prostatic hyperplasia	GA90	Phase 3	[1]
Prostate cancer	2C82.0	Phase 3	[1]

• Cross-matching ID:
  PubChem CID: 11679580
  TTD Drug ID: DM6P8HU

Molecule-Related Drug Atlas

Drug(s) Targeting Oxo-5-alpha-steroid 4-dehydrogenase (SRD5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Finasteride	DMWV3TZ	Baldness, male pattern		Approved	[3]
Dutasteride	DMQ4TJK	Benign prostatic hyperplasia	GA90	Approved	[3]
Polyestradiol Phosphate	DM0PMGJ	Prostate cancer	2C82.0	Approved	[4]
Azelaic Acid	DMHVL0J	Acne vulgaris	ED80	Approved	[5]
Epristeride	DM35T1O	Hirsutism	ED72	Phase 3	[6]
FK-143	DMEL15U	Prostate disease	GA91	Phase 2	[7]
Turosteride	DMW7PFS	Prostate disease	GA91	Phase 2	[8]
IZONSTERIDE	DM3KXMG	Hirsutism	ED72	Phase 1/2	[9]
ONO-3805	DM1RKWV	Prostate disease	GA91	Discontinued in Phase 3	[10]
CS-891B	DM17I8O	Alopecia	ED70	Discontinued in Phase 2	[11]

Drug(s) Targeting Adrenergic receptor alpha-1A (ADRA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SILODOSIN	DMJSBT6	Benign prostatic hyperplasia	GA90	Approved	[12]
NAFTOPIDIL	DMQ8R4E	Hypertension	BA00-BA04	Approved	[12]
Tamsulosin	DM5QF9V	Benign prostatic hyperplasia	GA90	Approved	[4]
Xatral	DMLHOA0	Benign prostatic hyperplasia	GA90	Approved	[13]
Besipirdine	DMLVNTA	Cognitive impairment	6D71	Phase 3	[14]
MEDETOMIDINE	DMX9Y7V	Pain	MG30-MG3Z	Phase 2	[15]
PMID30124346-Compound-LDT8	DM5MUNG	Benign prostatic hyperplasia	GA90	Patented	[16]
PMID30124346-Compound-LDT66	DMJMTNL	Benign prostatic hyperplasia	GA90	Patented	[16]
TIOSPIRONE	DME5QDP	N. A.	N. A.	Discontinued in Phase 3	[17]
Sunepitron	DM6M8ZX	N. A.	N. A.	Discontinued in Phase 3	[18]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor alpha-1A (ADRA1A)	TTNGILX	ADA1A_HUMAN	Antagonist	[2]
Oxo-5-alpha-steroid 4-dehydrogenase (SRD5A)	TT2A0DR	S5A1_HUMAN; S5A2_HUMAN; PORED_HUMAN	Inhibitor	[2]

References

• [1] ClinicalTrials.gov (NCT00090103) Benign Prostatic Hyperplasia Trial With Dutasteride And Tamsulosin Combination Treatment. U.S. National Institutes of Health.
• [2] Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
• [3] The role of 5-alpha reductase inhibitors in prostate pathophysiology: Is there an additional advantage to inhibition of type 1 isoenzyme Can Urol Assoc J. 2009 Jun;3(3 Suppl 2):S109-14.
• [4] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [5] Inhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acid. Br J Dermatol. 1988 Nov;119(5):627-32.
• [6] Discovery of a novel hybrid from finasteride and epristeride as 5alpha-reductase inhibitor. Bioorg Med Chem Lett. 2011 Jan 1;21(1):475-8.
• [7] FK143, a novel nonsteroidal inhibitor of steroid 5 alpha-reductase: (1) In vitro effects on human and animal prostatic enzymes. J Steroid Biochem Mol Biol. 1995 Apr;52(4):357-63.
• [8] Hormonal effects of turosteride, a 5 alpha-reductase inhibitor, in the rat. J Steroid Biochem Mol Biol. 1993 Nov;46(5):549-55.
• [9] Phase I and clinical pharmacology of a type I and II, 5-alpha-reductase inhibitor (LY320236) in prostate cancer: elevation of estradiol as possible... Urology. 2004 Jan;63(1):114-9.
• [10] Significant role of 5 alpha-reductase on feedback effects of androgen in rat anterior pituitary cells demonstrated with a nonsteroidal 5 alpha-redu... J Androl. 1994 Nov-Dec;15(6):521-7.
• [11] The novel drug CS-891 inhibits 5alpha-reductase activity in freshly isolated dermal papilla of human hair follicles. Eur J Dermatol. 2000 Dec;10(8):593-5.
• [12] Pharmacophore identification of alpha(1A)-adrenoceptor antagonists. Bioorg Med Chem Lett. 2005 Feb 1;15(3):657-64.
• [13] Pharma & Vaccines. Product Development Pipeline. April 29 2009.
• [14] Alpha-Adrenergic activity and cardiovascular effects of besipirdine HCl (HP 749) and metabolite P7480 in vitro and in the conscious rat and dog. J Pharmacol Exp Ther. 1997 Apr;281(1):337-46.
• [15] A structure-activity relationship study of benzylic modifications of 4-[1-(1-naphthyl)ethyl]-1H-imidazoles on alpha 1- and alpha 2-adrenergic recep... J Med Chem. 1994 Jul 22;37(15):2328-33.
• [16] 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689.
• [17] 3-Benzisothiazolylpiperazine derivatives as potential atypical antipsychotic agents. J Med Chem. 1996 Jan 5;39(1):143-8.
• [18] An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment o... J Med Chem. 2006 Jun 1;49(11):3116-35.