Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6S157)

Drug Name

Guanadrel Sulfate Drug Info

Synonyms

Hylorel; Hyloride; Guanadrel sulfate [USAN]; CL 1388R; U 28288D; CL-1388R; Guanadrel sulfate (USP); Hylorel (TN); U 28,288D; U-28288D; Guanadrel sulfate (2:1); Guanidine (1,4-dioxaspiro(4.5)dec-2-ylmethyl)-, sulfate (2:1); (1,4-Dioxaspiro(4.5)dec-2-ylmethyl)guanidine sulfate (2:1); 2-(1,4-dioxaspiro[4.5]decan-3-ylmethyl)guanidine

Indication

Disease Entry	ICD 11	Status	REF
Hypertension	BA00-BA04	Approved	[1]

Therapeutic Class

Antihypertensive Agents

Cross-matching ID

PubChem CID: 68552
ChEBI ID: CHEBI:5556
CAS Number: CAS 22195-34-2
TTD Drug ID: DM6S157

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

Discontinued Drug(s)

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Drug(s) Targeting Adrenergic receptor (ADR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Celiprolol hcl	DMD5LBX	Hypertension	BA00-BA04	Approved	[3]
Ovine corticotropin-releasing hormone	DME0F98	Cushing disease	5A70	Approved	[4]
Befunolol hci	DM8WCXM	Glaucoma/ocular hypertension	9C61	Approved	[3]
Oxilofrine	DMRKOS1	Orthostatic hypotension	BA21	Approved	[4]
Terbutyline	DMVPWLZ	Hypertension	BA00-BA04	Approved	[4]
Dabelotine	DMP2SGN	Cognitive impairment	6D71	Phase 3	[5]
AR08	DM93CTQ	Attention deficit hyperactivity disorder	6A05.Z	Phase 2	[6]
PMID30124346-Compound-60TABLE5	DM3QX0R	Dyskinesia	MB47.4	Patented	[7]
Etilefrine	DM67PWD	Cardiovascular disease	BA00-BE2Z	Withdrawn from market	[4]
AIR-Epinephrine	DMGAERX	Allergy	4A80-4A85	Discontinued in Phase 1	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor (ADR)	TTVIREA	NOUNIPROTAC	Modulator	[2]

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References

1	FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 018104.
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
3	Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
4	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
5	US patent application no. 2007,0049,576, Neurogenesis by muscarinic receptor modulation.
6	Optimizing treatments for nicotine dependence by increasing cognitive performance during withdrawal. Expert Opin Drug Discov. 2014 June; 9(6): 579-594.
7	5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689.
8	Prostaglandin synthesis inhibitors reverse alpha-adrenergic inhibition of acute insulin response to glucose. Am J Physiol. 1980 Dec;239(6):E490-500.