Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM74LZK)

Drug Name
Cromoglicate Drug Info
Synonyms Crolom (TN); Intal (TN); Nasalcrom (TN); Opticrom (TN); Optrex Allergy (TN); Prevalin (TN); Rynacrom (TN)
Indication
Disease Entry ICD 11 Status REF
Asthma CA23 Approved [1] , [2]
Allergic rhinitis CA08.0 Terminated [3]
Therapeutic Class
Antiasthmatic Agents
Cross-matching ID
PubChem CID
2882
ChEBI ID
CHEBI:59773
CAS Number
CAS 16110-51-3
TTD Drug ID
DM74LZK
ACDINA Drug ID
D00971

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Heat shock protein 90 alpha (HSP90A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amlexanox DM0DQM5 Respiratory tract inflammation CA07 Approved [4]
NVP-AUY922 DMTYXQF Multiple myeloma 2A83 Phase 2 [5]
BIIB-021 DMPAJ41 Breast cancer 2C60-2C65 Phase 2 [6]
KW-2478 DMJGL72 Solid tumour/cancer 2A00-2F9Z Phase 2 [7]
VER 50589 DMFLZPC Breast cancer 2C60-2C65 Phase 2 [5]
Tanespimycin DMNLQHK Breast cancer 2C60-2C65 Phase 2 [8]
Efungumab DMBHP56 Breast cancer 2C60-2C65 Phase 2 [9]
SNX-5422 DMIU0VP Haematological malignancy 2B33.Y Phase 1/2 [10]
PU3 DMJO0BP Solid tumour/cancer 2A00-2F9Z Phase 1 [5]
Debio 0932 DMWP3G1 Solid tumour/cancer 2A00-2F9Z Phase 1 [11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Heat shock protein 90 alpha (HSP90A) TT78R5H HS90A_HUMAN Inhibitor [4]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7608).
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3 Sodium cromoglicate: an ineffective drug or meta-analysis misused Pharm Stat. 2007 Apr-Jun;6(2):123-37.
4 Hsp90 is a direct target of the anti-allergic drugs disodium cromoglycate and amlexanox. Biochem J. 2003 Sep 1;374(Pt 2):433-41.
5 Recent advances in Hsp90 inhibitors as antitumor agents. Anticancer Agents Med Chem. 2008 Oct;8(7):761-82.
6 BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90. Mol Cancer Ther. 2009 Apr;8(4):921-9.
7 Anti-tumor activity against multiple myeloma by combination of KW-2478, an Hsp90 inhibitor, with bortezomib. Blood Cancer J. 2012 Apr;2(4):e68.
8 Tanespimycin: the opportunities and challenges of targeting heat shock protein 90. Expert Opin Investig Drugs. 2009 Jun;18(6):861-8.
9 Efungumab: a novel agent in the treatment of invasive candidiasis. Ann Pharmacother. 2009 Nov;43(11):1818-23.
10 SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hema... Blood. 2009 Jan 22;113(4):846-55.
11 Clinical pipeline report, company report or official report of Debiopharm (2011).